Evidence map›Paper›PMID 42918845›Full record

ArticleNature immunology2026

Serine protease inhibitor A3 is a soluble SIRPα ligand that suppresses inflammation and antitumor immunity.

Yufei Hou, Lei Huang, Chunhui Jin, Xiaolong Li, Yongxing Chen, Liguang Sun, Feng Wang, Yong Zhang, Ying Wang, Meijuan Zou and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yufei Hou *Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
Lei Huang *Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
Chunhui JinKey Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
Xiaolong LiKey Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
Yongxing ChenKey Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.ORCID http://orcid.org/0009-0005-0056-1136
Liguang SunKey Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
Feng WangKey Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.ORCID http://orcid.org/0009-0004-7162-255X
Yong ZhangKey Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
Ying WangKey Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
Meijuan ZouKey Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
Qina XuDepartment of Neurology, Neuroscience Center, The First Hospital of Jilin University, Changchun, China.
Zicheng WangDepartment of Neurology, Neuroscience Center, The First Hospital of Jilin University, Changchun, China.
Tao JinDepartment of Neurology, Neuroscience Center, The First Hospital of Jilin University, Changchun, China.
Naicui ZhaiKey Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
Fei XuKey Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
Wentao LiuKey Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China. liuwt@jlu.edu.cn.ORCID http://orcid.org/0000-0001-5534-7173
Yong-Guang YangKey Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China. yongg@jlu.edu.cn.ORCID http://orcid.org/0000-0003-4985-1247

Funding

National Natural Science Foundation of China (National Science Foundation of China) 8249100021Natural Science Foundation of Jilin Province (Natural Science Foundation of Jilin Province of China) 232707YY0103118582; 20230505029ZP
6 · The paper itself

Abstract

SIRPα is an inhibitory receptor with the canonical ligand CD47. Here, we show that human serine protease inhibitor A3 (SERPINA3) and its mouse ortholog SERPINA3k function as soluble binders and activators of SIRPα, suppressing SIRPα

Identifiers

PMID42918845

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.