Evidence map›Paper›PMID 42918832›Full record

ArticleOncogene2026

FATP5 loss in hepatocellular carcinoma cells orchestrates tumor-promoting microenvironment by inducing passive long-chain fatty acid accumulation within tumor-associated endothelial cells.

Chuli Fu, Wenyun Fu, Zhengwei Zhao, Xiaoyan He, Zuotian Huang, Teng Wei, Kelin Wu, Geyan Wu, Yuan Feng, Jincui Yang and 17 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Chuli Fu *Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Wenyun Fu *Department of Medical Oncology, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Zhengwei Zhao *Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xiaoyan He *Department of Pathology, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zuotian Huang *Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Teng WeiSchool of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, China.
Kelin WuBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Geyan WuBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Yuan FengBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Jincui YangBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xinrong HeBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Shuhui XuBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xuelong ZhengBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xiaoqiang ChenBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Kaiyue YaoBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Wenyi YinBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Yuexiang OuyangBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Yicai ChengBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xiaoyi ZhanBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xiaoli PanState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Yueyang HuInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Stephanie RoesslerInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5333-5942
Yunting JianDepartment of pathology, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, the Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. jianyunting@126.com.ORCID http://orcid.org/0009-0009-7095-3134
Jiang Qing-PingDepartment of pathology, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, the Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. jiangqingping@gzhmu.edu.cn.ORCID http://orcid.org/0000-0001-9572-2708
Junyao XuDepartment of hepatobiliary surgery, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, the Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. xujy@gzhmu.edu.cn.ORCID http://orcid.org/0000-0003-2884-9084
Guang-Rong YanBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. tgryan@jnu.edu.cn.ORCID http://orcid.org/0009-0009-4488-2766
Qiangnu ZhangBiomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Disease, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. qiangnuzhang@gzhmu.edu.cn.ORCID http://orcid.org/0000-0002-0386-1506

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82125029, 82073106, 82341016, and 82002956National Natural Science Foundation of China (National Science Foundation of China) 82472716
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is characterized by severe immunosuppression and metabolic reprogramming, yet the spatial dynamics of lipid flux between malignant and stromal cells remain poorly understood. Here, we identify a profound, type-specific metabolic rewiring in HCC driven by the widespread downregulation of fatty acid transport protein 5 (FATP5). FATP5 deficiency in malignant cells selectively attenuates the uptake of long-chain fatty acids (LCFAs), creating an extracellular lipid surplus that is passively sequestered by neighboring FATP3-expressing tumor-associated endothelial cells (TECs). Within TECs, accumulated LCFAs function as endogenous ligands that activate the nuclear receptor PPARγ, culminating in the robust transcriptional upregulation and paracrine secretion of the chemokine CXCL12. Endothelial-derived CXCL12 subsequently engages CXCR4 on infiltrating CD8

Identifiers

PMID42918832

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.