Evidence map›Paper›PMID 42918829›Full record

ArticlePediatric research2026

A complementary proteomics and cardiac magnetic resonance approach to characterize right ventricular remodeling after tetralogy of Fallot repair.

Andrea L Jones, Jonathan J Edwards, Hossein Fazelinia, David Frank, Katie L Clouthier, Chandni Patel, Lynn Spruce, Hua Ding, Julia Sabella, Catherine M Avitabile and 5 more

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Andrea L Jones *Division of Cardiology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. JonesA21@chop.edu.
Jonathan J Edwards *Division of Cardiology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hossein FazeliniaChildren's Hospital of Philadelphia-University of Pennsylvania Proteomics Core, Leonard and Madlyn Abramson Pediatric Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
David FrankDivision of Cardiology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Katie L ClouthierDepartment of Pediatrics (Cardiology), Lucile Packard Children's Hospital and the Cardiovascular Institute, Stanford University, Palo Alto, CA, USA.
Chandni PatelDivision of Cardiology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lynn SpruceChildren's Hospital of Philadelphia-University of Pennsylvania Proteomics Core, Leonard and Madlyn Abramson Pediatric Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Hua DingChildren's Hospital of Philadelphia-University of Pennsylvania Proteomics Core, Leonard and Madlyn Abramson Pediatric Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Julia SabellaDivision of Cardiology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Catherine M AvitabileDivision of Cardiology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mark K FriedbergThe Labatt Family Heart Center, Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Mark A FogelDivision of Cardiology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Harry IschiropoulosChildren's Hospital of Philadelphia-University of Pennsylvania Proteomics Core, Leonard and Madlyn Abramson Pediatric Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sushma ReddyDepartment of Pediatrics (Cardiology), Lucile Packard Children's Hospital and the Cardiovascular Institute, Stanford University, Palo Alto, CA, USA.
Laura Mercer-RosaDivision of Cardiology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with repaired tetralogy of Fallot (TOF) can develop right ventricular (RV) dilation and failure. We sought to utilize an untargeted serum proteomics approach to characterize the proteome signature associated with RV dilation in repaired TOF to improve the understanding of mechanistic drivers of RV remodeling.

methodsPatients with repaired TOF undergoing cardiac magnetic resonance imaging were recruited. Groups were based on indexed RV end-diastolic volume (RVEDVi). Serum proteomics identified differentially abundant proteins (p value < 0.05), and pathway enrichment identified functional pathways.

resultsFourteen TOF adolescents (median age 16 years; IQR 15, 18) were divided into Group 1 (n = 9; median RVEDVi 146 ml/m

conclusionPatients with repaired TOF and moderate-severe RV dilation have a distinct serum proteomic profile despite preserved ejection fraction, which may reflect alterations in fuel sources and oxidative stress. These hypothesis-generating findings are a first step in the integration of proteomics into clinical management. IMPACT: An untargeted serum proteomics approach to identifying altered protein profiles associated with CMR-defined RV dilation is a novel approach to characterizing right ventricular remodeling after tetralogy of Fallot repair. RV dilation after repair of tetralogy of Fallot is associated with a specific proteomic profile suggesting adaptive and maladaptive remodeling. Identification of dysregulated proteins associated with RV remodeling provides insight into the mechanisms leading to ventricular failure after tetralogy of Fallot repair. With additional data from future larger studies, serum proteomics evaluation may assist in prognostication and clinical decision making in patients after tetralogy of Fallot repair.

Identifiers

PMID42918829

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