Evidence map›Paper›PMID 42918811›Full record

ArticleNature communications2026

Chronic stress activates a hypothalamic vagal circuit to promote hepatocellular carcinoma progression in male mice.

Kun Zhang, Jianxing Zhang, Dongmei Chi, Zhaoli He, Sudena Wang, Xitong Zheng, Rongping Guo, Weian Zeng, Handong Ouyang, Chaopeng Ou and 1 more

Abstract read
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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kun Zhang *Department of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.
Jianxing Zhang *Department of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.
Dongmei Chi *Department of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.ORCID http://orcid.org/0000-0002-6565-588X
Zhaoli He *Department of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.
Sudena Wang *Department of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.
Xitong ZhengDepartment of Anesthesiology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Rongping GuoDepartment of Hepatic Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Weian ZengDepartment of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China. zengwa@mail.sysu.edu.cn.
Handong OuyangDepartment of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China. ouyhd@sysucc.org.cn.ORCID http://orcid.org/0000-0003-3992-9653
Chaopeng OuDepartment of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China. oucp@sysucc.org.cn.ORCID http://orcid.org/0000-0002-0401-4659
Xiaohui BaiDepartment of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China. baixhui@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-3501-8246

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82071237National Natural Science Foundation of China (National Science Foundation of China) 82401437Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2026A1515012403
6 · The paper itself

Abstract

Hepatocellular carcinoma and depression frequently co-occur, yet the mechanisms linking them remain unclear. Here, we show that chronic stress, systemic inflammation, or neuropathic pain are associated with hepatocellular carcinoma progression in male mice. Chronic stress hyperactivates a glutamatergic paraventricular hypothalamic nucleus → cholinergic dorsal motor nucleus of the vagus → liver circuit, increasing intratumoral acetylcholine. Single-cell transcriptomics identifies acetylcholine-responsive Chrna9

Indexed as

Carcinoma, HepatocellularHypothalamusLiver NeoplasmsStress, PsychologicalVagus NerveAcetylcholineAnimalsCell ProliferationChemokine CXCL1DepressionDisease ProgressionHumansLiverMacrophagesMaleMiceAcetylcholineChemokine CXCL1Cxcl1 protein, mouseSTAT3 Transcription Factor

Identifiers

PMID42918811

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.