Evidence map›Paper›PMID 42918775›Full record

ArticleNature communications2026

Calcium induced N-terminal gating and pore collapse in connexin-46/50 gap junctions.

Jonathan A Flores, Susan E O'Neill, Joshua M Jarodsky, Bassam G Haddad, Steve L Reichow

Abstract read
PubMed Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jonathan A Flores *Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA.
Susan E O'Neill *Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA.
Joshua M Jarodsky *Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA.
Bassam G HaddadInstitute of Neurophysiology, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0003-1305-0261
Steve L ReichowDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR, USA. reichow@ohsu.edu.ORCID http://orcid.org/0000-0001-5276-7690

Funding

Pacific Northwest Center for Cryo-EM: Equipment SupplementR24GM154185 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Evans, CLAUDIA SUSANA LOPEZ · 2024 to 2026
$21.5M
High Performance Computing and Machine Learning Infrastructure for Oregon Life SciencesS10OD034224 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLROTT, KYLE · 2023 to 2023
$2.0M
Effect of lipid environment on the structure and organization of connexin-46/50 gap junction channelsF31EY030409 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI FLORES, JONATHAN ALEX · 2019 to 2021
$136k
U.S. Department of Health & Human Services | National Institutes of Health (NIH) F31EY030409U.S. Department of Health & Human Services | National Institutes of Health (NIH) R24GM154185U.S. Department of Health & Human Services | National Institutes of Health (NIH) S10OD034224
6 · The paper itself

Abstract

Gap junctions facilitate electrical and metabolic coupling essential for tissue function. Under ischemic conditions (e.g., heart attack or stroke), elevated intracellular calcium (Ca²

Indexed as

CalciumConnexinsGap JunctionsIon Channel GatingAnimalsConnexin 50Cryoelectron MicroscopyHumansMolecular Dynamics SimulationProtein ConformationProtein DomainsCalciumConnexin 50ConnexinsGJA3 protein, human

Identifiers

PMID42918775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.