Evidence map›Paper›PMID 42918758›Full record

ArticleNature communications2026

Loss of intestinal Akt elicits rapid mortality via intestinal damage which is rescued by mTORC1 activation.

Ahmed Magdy, Hyunsoo Rho, Muzamil Mushtaq, William Putzbach, Veronique Nogueira, Vaibhav Chand, Nissim Hay

Abstract read
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In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmed MagdyDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-8100-2141
Hyunsoo RhoDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA. hrho@ewha.ac.kr.ORCID http://orcid.org/0009-0004-2636-4416
Muzamil MushtaqDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0009-0003-8179-1472
William PutzbachDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Veronique NogueiraDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-3289-1760
Vaibhav ChandDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Nissim HayDepartment of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA. nhay@uic.edu.ORCID http://orcid.org/0000-0002-6245-3000

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combined Akt1 and Akt2 systemic deletion in adult mice elicits rapid mortality, preceded by body weight loss, diarrhea, and inflammation. Here, we show that lethality induced by systemic Akt1/Akt2 deletion is caused by intestinal damage, as intestinal Akt1/Akt2 deletion induces mortality phenocopying systemic deletion. Consistently, Akt ablation impairs intestinal organoid formation in vitro. Both in vivo and in vitro results show that Akt is essential for the survival of Paneth cells and survival and proliferation of Lgr5

Indexed as

IntestinesMechanistic Target of Rapamycin Complex 1Proto-Oncogene Proteins c-aktAnimalsCell ProliferationForkhead Box Protein O1Intestinal MucosaMiceMice, Inbred C57BLMice, KnockoutRegulatory-Associated Protein of mTORSignal TransductionTuberous Sclerosis Complex 1 ProteinAkt1 protein, mouseAkt2 protein, mouseForkhead Box Protein O1Foxo1 protein, mouseMechanistic Target of Rapamycin Complex 1Proto-Oncogene Proteins c-aktRegulatory-Associated Protein of mTORRptor protein, mouseTsc1 protein, mouseTuberous Sclerosis Complex 1 Protein

Identifiers

PMID42918758

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.