Evidence map›Paper›PMID 42918749›Full record

ArticleCell death discovery2026

Mechanisms of cardiomyocyte dysfunction induced by extracellular histones.

Moza M Al-Owais, Zhaokang Yang, Derek S Steele, Arun V Holden

Abstract read
PubMed Publisher
In one paragraph

Article in Cell death discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Moza M Al-OwaisSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK. m.al-owais@leeds.ac.uk.ORCID http://orcid.org/0000-0001-9122-7873
Zhaokang YangSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Derek S SteeleSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Arun V HoldenSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

Funding

British Heart Foundation (BHF) PG/19/68/34614
6 · The paper itself

Abstract

Circulating histones released from damaged cells cause secondary impairment to organs, including the heart. Here, we investigate their effects and the underlying pathological mechanisms on isolated ventricular cardiomyocytes. Exogenous H3 or H4 (0.01-1 µg ml

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.