Evidence map›Paper›PMID 42912214›Full record

ArticleOrganic letters2026

Catalytic Stereoselective Intermolecular Fluoroacylation of Unactivated Alkynes via C-F Bond Reconstruction.

Tanmay Kanji, Asma A Alharthi, Abdulrahman H Husayni, Pippa Wainwright, Thomas Wirth, Rebecca L Melen, Louis C Morrill

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tanmay KanjiCardiff Catalysis Institute, School of Chemistry, Cardiff University, Translational Research Hub, CardiffCF24 4HQ, United Kingdom.
Asma A AlharthiSchool of Chemistry, Cardiff University, Main Building, Park Place, CardiffCF10 3AT, United Kingdom.
Abdulrahman H HusayniSchool of Chemistry, Cardiff University, Main Building, Park Place, CardiffCF10 3AT, United Kingdom.
Pippa WainwrightChemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, MacclesfieldSK10 2NA, United Kingdom.
Thomas WirthSchool of Chemistry, Cardiff University, Main Building, Park Place, CardiffCF10 3AT, United Kingdom.
Rebecca L MelenCardiff Catalysis Institute, School of Chemistry, Cardiff University, Translational Research Hub, CardiffCF24 4HQ, United Kingdom.ORCID 0000-0003-3142-2831
Louis C MorrillDepartment of Chemistry, University of Bath, Claverton Down, BathBA2 7AY, United Kingdom.ORCID 0000-0002-6453-7531

Funding

AstraZeneca NAEngineering and Physical Sciences Research Council EP/W524682/1Jazan University NASchool of Chemistry, Cardiff University NAUniversity of Bath NAUniversity of Jeddah NA
6 · The paper itself

Abstract

Herein, we report a transition metal-free synthesis of monofluoroalkenes via a C-F bond reconstruction approach. The process employs inexpensive BF3·Et2O as a catalyst for the stereoselective intermolecular fluoroacylation of unactivated alkynes with alkyl/aryl acid fluorides to access various monofluoroalkene products (24 examples, typically >98:<2 Z:E). The synthetic utility of the products was demonstrated via their conversion into various heterocycles (pyrazoles, isoxazoles, and pyrimidines) and fluoroalkene-containing esters/amides.

Identifiers

PMID42912214
PMCPMC13660379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.