ArticleOrganic letters2026
Polar and e-Radical Strain-Release Strategies for Accessing Functionalized 2-Oxabicyclo[2.1.1]hexan-3-ones from Bicyclo[1.1.0]butanes.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
2-Oxabicyclo[2.1.1]hexanes (OBHs) have emerged as valuable saturated aromatic replacements, whereas their lactone analogues, 2-oxabicyclo[2.1.1]hexan-3-ones (OBHOs) remain underexplored, because of limited synthetic access. Herein, we report complementary polar and electrochemical strain-release strategies for the modular synthesis of 1,4-difunctionalized OBHOs from bicyclo[1.1.0]butane carboxylic acids. The two activation modes provide complementary perspectives toward the chemical space expansion of this underexplored scaffold.
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