Evidence map›Paper›PMID 42912095›Full record

ArticleBrazilian oral research2026

Solubility of calcium silicate-based endodontic sealers in acidic and neutral pH using phosphate-free buffers.

Cláudio Malizia Alves Ferreira, Juliana da Silva Chagas Cypriano, Brenda Xavier Dos Santos, Vitória Cerqueira Soares, Karem Paula Pinto, Barbara de Paula Coelho, Luciana Moura Sassone, Emmanuel João Nogueira Leal da Silva

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian oral research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cláudio Malizia Alves FerreiraUniversidade do Estado do Rio de Janeiro - UERJ, School of Dentistry, Department of Integrated Clinical Procedures, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0002-4970-3757
Juliana da Silva Chagas CyprianoUniversidade do Estado do Rio de Janeiro - UERJ, School of Dentistry, Department of Integrated Clinical Procedures, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0003-3358-7760
Brenda Xavier Dos SantosUniversidade do Estado do Rio de Janeiro - UERJ, School of Dentistry, Department of Integrated Clinical Procedures, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0003-1132-9509
Vitória Cerqueira SoaresUniversidade do Estado do Rio de Janeiro - UERJ, School of Dentistry, Department of Integrated Clinical Procedures, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0009-0002-2018-3601
Karem Paula PintoUniversidade do Estado do Rio de Janeiro - UERJ, School of Dentistry, Department of Integrated Clinical Procedures, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0001-5642-9541
Barbara de Paula CoelhoUniversidade do Estado do Rio de Janeiro - UERJ, School of Dentistry, Department of Integrated Clinical Procedures, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0001-9501-3944
Luciana Moura SassoneUniversidade do Estado do Rio de Janeiro - UERJ, School of Dentistry, Department of Integrated Clinical Procedures, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0002-6181-7490
Emmanuel João Nogueira Leal da SilvaUniversidade do Estado do Rio de Janeiro - UERJ, School of Dentistry, Department of Integrated Clinical Procedures, Rio de Janeiro, RJ, Brazil.ORCID http://orcid.org/0000-0002-6445-8243

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the solubility of calcium silicate-based endodontic sealers under acidic and neutral pH conditions using phosphate-free buffered solutions. The solubility of three calcium silicate-based sealers (BioRoot RCS, Bio-C Sealer, and AH Plus Bioceramic) and an epoxy resin-based sealer (AH Plus Jet) was evaluated according to ISO 6876:2012 guidelines, with modifications. Specimens (n = 12 per sealer) were immersed in phosphate-free buffered solutions at pH 5 and 7 and stored at 37°C for 24 hours, 7 days, and 30 days. Solubility was calculated as the percentage of initial mass loss. Statistical analyses were conducted using one-way ANOVA, Tukey's post hoc test, and independent t-tests (p < 0.05). AH Plus Jet met ISO 6876:2012 solubility standards at all time points, while all calcium silicate-based sealers exceeded the acceptable limit. Acidic pH significantly increased the solubility of these sealers (p < 0.05), except for BioRoot RCS at 30 days. Among the calcium silicate-based sealers, BioRoot RCS exhibited the lowest solubility, followed by Bio-C Sealer, whereas AH Plus Bioceramic showed the highest solubility and disintegrated after 7 days, preventing evaluation at 30 days. In contrast, AH Plus Jet remained stable under both pH conditions, exhibiting a slight mass gain over time. Overall, acidic pH increased the solubility of calcium silicate-based sealers, whereas AH Plus Jet remained stable and compliant with ISO 6876:2012 standards.

Indexed as

Calcium CompoundsRoot Canal Filling MaterialsSilicatesAnalysis of VarianceBuffersEpoxy ResinsHydrogen-Ion ConcentrationMaterials TestingPhosphatesReference ValuesReproducibility of ResultsSolubilityTime FactorsBuffersCalcium Compoundscalcium silicateepoxy resin-based root canal sealerEpoxy ResinsPhosphatesRoot Canal Filling MaterialsSilicates

Identifiers

PMID42912095
PMCPMC13679065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.