ReviewRevista da Sociedade Brasileira de Medicina Tropical2026
Safety of tuberculosis-preventive treatment in children aged under 5 years: A rapid review.
Review in Revista da Sociedade Brasileira de Medicina Tropical, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to synthesize evidence on the safety of tuberculosis-preventive treatment (TPT) in children aged <5 years, including those with immunocompromising conditions.
methodsA rapid review was conducted using PubMed, Embase, Virtual Health Library, and the Cochrane Library, including systematic reviews and primary studies.
resultsFive studies were included, assessing isoniazid-based regimens. Adverse events were mild and reversible, such as transient liver enzyme elevations and peripheral neuropathy. Severe hepatotoxicity was rare and primarily reported in children with Human Immunodeficiency Virus (HIV).
conclusionsTPT appears generally safe in children aged <5 years; however, evidence remains limited for shorter regimens and immunocompromised populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.