ArticleBrazilian dental journal2026
Antibacterial activity and biofilm inhibition of a novel bioactive glass coating (F18) on titanium discs.
Article in Brazilian dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study aimed to investigate the anti-biofilm and bactericidal activity of biofunctionalized titanium with either nanohydroxyapatite or F18 bioactive glass against Staphylococcus aureus biofilms. For that, discs (6.0mm diameter and 3.0 mm thickness) with different surface treatments were studied and divided into three groups: 1) machined titanium (M); 2) coated with Nano-hydroxyapatite (Nano-Ha); 3) Biofunctionalized with F18 bioactive glass (BSF18). Surface characterization was investigated through energy-dispersive spectroscopy, scanning electron microscopy, atomic force microscopy, and bioactivity assays. Antibacterial activity was investigated according to the JIS Z 2801:2010 standard and ISO 22196:2011. The samples were evaluated for UFC/mL, biofilm morphology, and confocal laser scanning microscopy was performed after 24 h. The results showed that BSF18 biofunctionalized discs significantly reduced viable bacterial adhesion compared with Nano-Ha and M groups (3.93±0.14; 5.68±0.26; and 5.57±0.16; p<0.0001; respectively). The morphology analysis revealed a smaller number of adhered bacterial cells for BSF18 samples when compared to the M and Nano-HA, additionally, the biofunctionalization of titanium discs with F18 bioactive glass was effective in inhibiting the growth of Staphylococcus aureus biofilm after direct contact for 24 hours analyzed by confocal laser microscopy which demonstrated greater values for dead cells and lesser live cells for BSF18 surface when compared to machined and Nano-HA (p<0.05). F18 bioactive glass can be a promising biomaterial for preventing and controlling infection by S. aureus on titanium implants. It could be a valid infection-preventing strategy for implant dentistry clinical practice.
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