ArticleRevista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo2026
Umbilical cord blood miR-125b-5p: a diagnostic and prognostic biomarker for neonatal respiratory distress syndrome.
Article in Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveNeonatal respiratory distress syndrome (NRDS) is a common respiratory disease. This study aimed to detect the expression of miR-125b-5p in the umbilical cord blood of NRDS patients and to evaluate its diagnostic and prognostic value.
methodsFluorescence-based real-time quantitative polymerase chain reaction was used to detect miR-125b-5p expression in the umbilical cord blood of NRDS patients and controls. The correlation between miR-125b-5p expression and NRDS clinical data was analyzed. Survival was analyzed using the Kaplan-Meier method. Cox regression identified risk factors for adverse outcomes, and the ROC curve evaluated diagnostic and prognostic accuracy.
resultsThe level of miR-125b-5p in NRDS patients was higher than that in controls. High miR-125b-5p expression was correlated with C-reactive protein levels, umbilical artery blood gas parameters, and the lung ultrasound score. Patients with high miR-125b-5p expression had significantly shorter event-free survival (HR 2.358, 95%CI 1.345-4.133, p<0.05) and long-term survival (HR 2.489, 95%CI 1.201-5.161, p<0.05). Cox regression identified high miR-125b-5p expression, high lung ultrasound score, high PaCO₂, and high PaO₂ as prognostic factors.
conclusionsUmbilical cord blood miR-125b-5p is highly expressed in NRDS. It may serve as a biomarker for the diagnosis and prognosis of NRDS.
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