Evidence map›Paper›PMID 42911531›Full record

ArticleJapanese journal of radiology2026

Dissociable associations of free-water fraction and DTI-ALPS index with disease manifestation and mutation carrier status in Parkinson's disease.

Chang Liu, Xi Liu, Meng Dong, Wenze Li, Hongfa Zhang, Lu Zhang, Yuqing Zhang, Yangmei Chen

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Article in Japanese journal of radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Chang LiuDepartment of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.ORCID http://orcid.org/0000-0002-6371-6976
Xi LiuDepartment of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Meng DongDepartment of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Wenze LiDepartment of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Hongfa ZhangDepartment of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Lu ZhangDepartment of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Yuqing ZhangDepartment of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. yqzhang@cqmu.edu.cn.
Yangmei ChenDepartment of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. chenym1997@cqmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeParkinson's disease (PD) is a biologically heterogeneous disorder. Diffusion MRI-derived free-water fraction (FW MATERIALS AND

methodsDiffusion MRI data from the Parkinson's Progression Markers Initiative were analyzed, including healthy controls (HCs), non-manifesting mutation carriers (NMCs), and patients with sporadic or genetic PD. A 2 × 2 factorial analysis of covariance was performed to assess the effects of disease status and mutation carrier status on SNc FW

resultsAmong 284 participants (63 HCs, 48 NMCs, 126 sporadic PD patients, and 47 genetic PD patients), mean SNc FW

conclusionsSNc FW

Indexed as

Analysis along the perivascular spaceFree waterGenetic susceptibilityParkinson’s diseaseSubstantia nigra

Identifiers

PMID42911531

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