ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2026
Lipidomic profiling of peritoneal lavage supernatant identifies PE/PA/PI-enriched recurrence biomarkers in cytology-negative gastric cancer.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
backgroundPeritoneal dissemination accounts for more than 40% of recurrences after radical gastrectomy for gastric cancer. Although peritoneal lavage cytology (CY) is routinely used to detect intraperitoneal free cancer cells, peritoneal recurrence still occurs in a subset of CY-negative patients. Novel molecular biomarkers are urgently needed to identify high-risk individuals within this cohort.
methodsDirect flow injection quadrupole time-of-flight mass spectrometry (DFI-Q-TOF-MS) in negative ion mode was applied to profile peritoneal lavage supernatants from gastric cancer patients stratified by recurrence outcome (CY-R + vs. CY-R-). Candidate recurrence-associated features were selected by volcano plot, LASSO logistic regression, and Random Forest. PLS-DA with VIP scores was applied for stage-associated feature identification.
resultsA recurrence-associated lipid signature was identified comprising phosphatidylethanolamine species (PE (34:0), PE (34:1), PE (38:1), PE O-38:5), phosphatidic acid PA (39:3), phosphatidylinositol PI (22:1), and oxidized sphingoid base SPB (18:3;O2), implicating membrane remodeling, lipid signaling pathway alterations, and oxidative stress in the peritoneal microenvironment of recurrence-prone patients.
conclusionThis study presents an exploratory lipidomic characterization of peritoneal lavage supernatant in CY-negative gastric cancer, identifying hypothesis-generating candidate lipid features associated with recurrence status. Given the small recurrence group and absence of external validation, all findings should be interpreted as exploratory and require confirmation in prospective multicenter studies.
Indexed as
Identifiers
42911524What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.