ArticleMolecular neurobiology2026
Design and Synthesis of Novel β-Naphthol Dithiocarbamate Hybrids: A Convergent Multifaceted Approach Towards AChE and Amyloid-β Inhibition for Alzheimer's Disease.
Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alzheimer's disease (AD) is an irreversible and chronic neurodegenerative disease, posing a growing global health burden, necessitating the development of multitarget-directed ligands (MTDLs) to combat its complex, multifactorial pathology. In this research, a new series of β-naphthol-based dithiocarbamate derivatives (5a-5g) were designed, synthesized using a rational drug design approach, and their structures were elucidated using FTIR, UV, and NMR spectra analysis. Reportedly, compound 5d showed characteristic C-N, C = S, and C-S vibrations in FTIR, while distinct aromatic and piperidinyl proton signals were detected in NMR. The compounds were screened for pre-ADME, molecular docking, and DFT study. The in silico studies predicted favorable binding capabilities against acetylcholinesterase (AChE) and amyloid-β (Aβ) targets. The antioxidant and biochemical estimation of the synthesized β-naphthol-based dithiocarbamate derivatives was evaluated using several in vitro assays, among which compound 5d exhibited the highest free radical scavenging activity and anti-AChE activity (IC
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