Evidence map›Paper›PMID 42911447›Full record

ArticleCardiovascular toxicology2026

Serum Proteoglycan Alterations Associated with Cardiovascular Risk in Pb-Battery Recycling Workers Using Exploratory Proteomics and Independent ELISA Validation.

Kartikey Matte, Shubhangi Pingle, Rajani Tumane, Manjula Kannasandra Ramaiah, Kalahasthi Ravibabu

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Cardiovascular toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kartikey MatteExtramural Lead Toxicity Project, Hosted at ICMR - Regional Occupational Health Centre (Southern) (ICMR-ROHC(S)), NIOHR, Bengaluru, Karnataka, 562110, India.
Shubhangi PingleDepartment of Biochemistry, ICMR - Regional Occupational Health Centre (Southern), NIOHR, Bengaluru, 562110, Karnataka, India. pingle.shubhangi@gmail.com.ORCID http://orcid.org/0000-0002-7742-7809
Rajani TumaneDepartment of Biochemistry, ICMR - Regional Occupational Health Centre (Southern), NIOHR, Bengaluru, 562110, Karnataka, India.
Manjula Kannasandra RamaiahDepartment of Biotechnology, School of Applied Sciences, REVA University, Bengaluru, Karnataka, 560064, India. manjula.kr@reva.edu.in.
Kalahasthi RavibabuDepartment of Biochemistry, ICMR - Regional Occupational Health Centre (Southern), NIOHR, Bengaluru, 562110, Karnataka, India.

Funding

Indian Council of Medical Research F2-2021-11436
6 · The paper itself

Abstract

Lead (Pb) is a prevalent environmental and occupational toxin that disrupts several biological systems. Its toxicological effects are well known but serum proteomic alterations associated with Pb remain insufficiently characterized. This study investigated serum proteomic changes in Pb-battery recycling workers (Pb-BRW) to identify the candidate proteins associated with Pb exposure using high-resolution mass spectrometry (HRMS). Blood samples (5 mL) were collected from Pb-BRW (n = 78) and age-matched unexposed controls (n = 65) from three industries in Karnataka, India. Blood Pb levels were assessed using inductively coupled plasma-optical emission spectroscopy. Serum samples (n = 10) pooled from each group were analyzed using quantitative discovery HRMS. Data are available via ProteomeXchange with identifier PXD082567. Raw files were processed using Proteome Discoverer, and proteins were identified using the UniProt Homo sapiens reviewed database. Further data were analysed in Perseus with log

Indexed as

Cardiovascular DiseasesLeadLumicanOccupational ExposureOccupational HealthProteoglycansProteomicsAdultBiomarkersCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleHeart Disease Risk FactorsHumansIndiaMaleBiomarkersLeadLumicanLUM protein, humanProteoglycansAtherosclerosisCardiovascularLeadLumicanProteoglycansProteomics

Identifiers

PMID42911447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.