Evidence map›Paper›PMID 42911266›Full record

SynthesisJournal of neurology2026

Locus coeruleus abnormalities on neuromelanin-sensitive MRI in Parkinson's disease: a systematic review and meta-analysis.

Jiale Zhao, Naibijiang Abuliezi, Rurui Wei, Yihan Sun, Alimire Aikemu, Junyan Lei, Yanyan Wu, Beisha Tang, Jifeng Guo, Qinfen Wu

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiale Zhao *The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Naibijiang Abuliezi *The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Rurui Wei *The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Yihan SunThe Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Alimire AikemuThe Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Junyan LeiThe Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Yanyan WuThe Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Beisha TangThe Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Jifeng GuoThe Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China. guojifeng2003@163.com.
Qinfen WuThe Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China. wqfcat@yeah.net.ORCID http://orcid.org/0009-0006-0550-2802

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 82471267the General Program of the Natural Science Foundation of the Xinjiang Uygur Autonomous Region Science and Technology Department 2024D01C150the Science and Technology Supporting Xinjiang Project 2024E02051the "Tianshan Talents" Medical and Health High-level Talent Training Program TSYC202301A024the "Tianshan Talents" Medical and Health High-level Talent Training Program TSYC202401A064
6 · The paper itself

Abstract

Neuromelanin-sensitive magnetic resonance imaging (NM-MRI) enables in vivo assessment of locus coeruleus (LC) integrity, but findings in Parkinson's disease (PD) vary across cohorts and methods. We searched PubMed/MEDLINE, Embase, Web of Science Core Collection and Scopus from inception to 5 September 2026 and pooled independent PD-healthy control (HC) comparisons using random-effects models. Sixty-five reports were included, of which 17 contributed to at least one main pooled outcome. The primary LC-signal analysis included 14 independent cohorts (1,078 participants with PD and 543 HCs) and showed lower LC signal in PD (Hedges' g = - 0.95, 95% confidence interval (CI) - 1.32 to - 0.57; P = 0.00011). Between-study heterogeneity was substantial (I

Indexed as

Locus CoeruleusMagnetic Resonance ImagingMelaninsParkinson DiseaseHumansMelaninsneuromelaninLocus coeruleusMeta-analysisNeuromelanin-sensitive MRIParkinson’s diseaseSystematic review

Identifiers

PMID42911266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.