Observational studyPhysiotherapy research international : the journal for researchers and clinicians in physical therapy2026
Dizziness, Lower Limb Weakness, and Falls in COPD: A Prospective Longitudinal Pilot Study Using Monthly Home Diaries.
Observational study in Physiotherapy research international : the journal for researchers and clinicians in physical therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06827379 (Acute Effects of Inspiratory Muscle Training With Different Loads on Peripheral Muscle Metabolism and Autonomic Response in COPD Patients), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acute Effects of Inspiratory Muscle Training With Different Loads on Peripheral Muscle Metabolism and Autonomic Response in COPD Patients: A Randomized Crossover Trial
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
background and purposeFalls affect approximately half of individuals with chronic obstructive pulmonary disease (COPD) and are associated with hospitalization, accelerated functional decline, and early institutionalization. Existing evidence suggests that single-visit assessments have limited and inconsistent ability to predict the future falls in individuals with COPD, highlighting the need for alternative longitudinal approaches. To our knowledge, this is the first prospective study to explore the longitudinal association between diary-recorded symptoms and falls in COPD.
methodsProspective observational cohort pilot study (n = 27), with 6-month follow-up. Falls and seven symptom variables were recorded monthly via structured home diaries, complemented by a standardised monthly telephone/messaging follow-up. Receiver operating characteristic (ROC) curves with 95% bootstrap confidence intervals (CI) and optimal cut-off points using the Youden index were calculated, with internal validation by optimism-correction bootstrap. Mann-Whitney U tests compared groups (α = 0.05).
resultsThirteen patients (48.1%) experienced at least one fall. Dizziness showed the strongest discrimination in this sample (area under the ROC curve [AUC] = 0.813; optimism-corrected 0.81; p = 0.002; optimal cut-off ≥ 1 month; specificity 85.7%; positive likelihood ratio [+LR] 4.84). Lower limb weakness for ≥ 2 months was the most sensitive discriminating variable (AUC = 0.739; p = 0.034; sensitivity 92.3%). Among baseline physiological measures, only the FEV1/FVC ratio showed acceptable discrimination (AUC = 0.734; p = 0.041), in a paradoxical direction (higher among fallers); Timed Up and Go, maximal inspiratory pressure, and quadriceps ultrasound did not significantly discriminate fallers from non-fallers. DISCUSSION: Longitudinal symptom monitoring via monthly home diaries showed higher apparent discrimination than single-visit baseline assessments in this pilot sample. These findings are exploratory and hypothesis-generating, supporting a confirmatory study with an adequate sample size. Monthly diary monitoring is low-cost, feasible by telephone, and may represent a complementary approach to fall risk assessment in COPD.
trial registrationRegistered on ClinicalTrials.gov, identifier NCT06827379 (PI: Eduardo Eriko Tenório de França).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.