ArticlePulmonary circulation2026
Right Ventricular-Pulmonary Arterial Coupling by Serial TAPSE/sPAP: A Noninvasive Predictor for Clinical Outcomes in Chronic Thromboembolic Pulmonary Hypertension.
Jing Wen, Ruzetuoheti Yiminniyaze, Yishan Li, Sugang Gong, Ling Zhu, Yuanhua Yang, Cheng Hong, Zhenwen Yang, Jun Wan, Xiaopei Cui and 22 more
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In one paragraphArticle in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
32 authors.
Jing WenChina-Japan Friendship Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
Ruzetuoheti YiminniyazeChina-Japan Friendship Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
Yishan LiDepartment of Pulmonary and Critical Care Medicine, Beijing Chaoyang Hospital Capital Medical University Beijing China.
Cheng HongDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Diseases, Guangdong Key Laboratory of Vascular Diseases, Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Guangdong China.ORCID https://orcid.org/0000-0002-0710-8757 Zhenwen YangDepartment of Cardiology Tianjin Medical University General Hospital Tianjin China.
Jun WanDepartment of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital Capital Medical University Beijing China.
Hong ChenDepartment of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing China.
Yingqun JiDepartment of Pulmonary and Critical Care Medicine, East Hospital Tongji University School of Medicine Shanghai China.
Chenghong LiDepartment of Pulmonary and Critical Care Medicine Affiliated Hospital of Jianghan University Wuhan Hubei China.
Zhaozhong ChengDepartment of Pulmonary and Critical Care Medicine The Affiliated Hospital of Qingdao University Qingdao Shandong China.
Changming XiongState Key Laboratory of Cardiovascular Disease, Department of Pulmonary Vascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.ORCID https://orcid.org/0000-0001-7468-5039 Lan WangDepartment of Pulmonary Circulation, Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai China.
Zhu ZhangNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine China-Japan Friendship Hospital Beijing China.ORCID https://orcid.org/0000-0002-7602-096X Yunxia ZhangNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine China-Japan Friendship Hospital Beijing China.
Qiang HuangNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine China-Japan Friendship Hospital Beijing China.ORCID https://orcid.org/0000-0002-5949-1225 Yanan ZhenDepartment of Cardiovascular Surgery China-Japan Friendship Hospital Beijing China.
Lei LiDepartment of Cardiology China-Japan Friendship Hospital Beijing China.
Aili LiDepartment of Cardiology China-Japan Friendship Hospital Beijing China.
Shuai ZhangNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine China-Japan Friendship Hospital Beijing China.ORCID https://orcid.org/0000-0003-3247-5847 Wanmu XieDepartment of Integrated Traditional Chinese and Western Medicine in Pulmonary Diseases, National Center for Respiratory Medicine; National Center for Integrated Traditional Chinese and Western Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Center of Respiratory Medicine China-Japan Friendship Hospital Beijing China.ORCID https://orcid.org/0000-0002-6686-3517 Zhenguo ZhaiNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine China-Japan Friendship Hospital Beijing China.ORCID https://orcid.org/0000-0002-7096-8792 Chen WangNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine China-Japan Friendship Hospital Beijing China.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The ratio of tricuspid annular plane systolic excursion to systolic pulmonary artery pressure (TAPSE/sPAP) is a noninvasive surrogate of right ventricular-pulmonary arterial coupling, but its value for dynamic risk stratification in chronic thromboembolic pulmonary hypertension (CTEPH) remains uncertain. This multicenter prospective cohort enrolled adults with CTEPH between 2016 and 2023. Patients were stratified by quartile-based baseline TAPSE/sPAP cutoffs into < 0.15, 0.15 to 0.30, and > 0.30. The primary outcome was clinical worsening (CW) within 12 months, comprising all-cause death, hospitalization for worsening pulmonary hypertension, escalation of pulmonary hypertension-targeted therapy, or a > 30% increase in pulmonary vascular resistance. Associations were examined using Kaplan-Meier, Cox regression, and time-dependent Cox analyses. Among 949 patients, 868 had follow-up and 212 (24.4%) experienced CW during a median follow-up of 10.3 months (interquartile range, 5.4-12.2 months). Lower baseline TAPSE/sPAP was associated with worse functional and hemodynamic profiles, and CW-free survival differed across strata (log-rank
Indexed as
clinical worseningechocardiographyhemodynamicsprognosisrisk stratification
Identifiers
PMID42910319
PMCPMC13686357
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