ArticleJournal of oral microbiology2026
Host-driven citrullination of extracellular vesicle-derived microbial proteins links
Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Rheumatoid arthritis (RA) is closely linked to citrullinated antigens and HLA-DRB1 risk alleles, yet the origin of immunogenic citrullinated peptides remains incompletely understood. While Methods: We developed a computational framework integrating known PADI4 and PPAD substrate preferences with MHC-II antigen presentation prediction. Human proteins were first stratified based on their susceptibility to PADI4 and/or PPAD-mediated citrullination, and their presentation profiles across RA risk-associated (HLA-DRB1*04:01 and 04:04) and protective (HLA-DRB1 Results: This analysis revealed distinct presentation signatures, including (a) global risk enrichment, (b) high-affinity binding bias, (c) characteristic allelic presentation ratios. Application of these three features led to the identification of five candidate proteins with potential relevance to RA risk, including gingipain R1 and four outer membrane proteins. Conclusions: These findings propose a hypothesis that host PADI4-mediated citrullination of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.