Evidence map›Paper›PMID 42910301›Full record

ArticleInternational journal of biological sciences2026

Sanguinarine Induces Pyroptosis

Jia Yang, Lanfang Li, Yunjian Pan, Wulei Hou, Xiaoyan Wang, Zhengda Li, Wenjie Wang, Yihua Sun, Ping Xu, Lifang Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jia YangDepartment of Oncology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Lanfang LiDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shanghai Pudong Hospital, Fudan University, Shanghai 200032, China.
Yunjian PanFudan University Shanghai Cancer Center, Shanghai 200032, China.
Wulei HouDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shanghai Pudong Hospital, Fudan University, Shanghai 200032, China.
Xiaoyan WangHuadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Zhengda LiDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shanghai Pudong Hospital, Fudan University, Shanghai 200032, China.
Wenjie WangBayinguoleng Mongolian Autonomous Prefecture Hygiene School, Xinjiang Province 841000, China.
Yihua SunFudan University Shanghai Cancer Center, Shanghai 200032, China.
Ping XuDepartment of Oncology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Lifang WangDepartment of Oncology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Ying LuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Zhongqi WangDepartment of Oncology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Zhenhui LuInstitute of Respiratory Diseases, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Zuoyun WangDepartment of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shanghai Pudong Hospital, Fudan University, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sanguinarine (SAN), a natural alkaloid derived from Papaveraceae plants, is an active component in traditional Chinese medicines. SAN exerts inhibitory effects on tumor cells, but research on its effects on lung adenocarcinoma (LUAD) and the underlying mechanisms remains limited. The Hippo signaling pathway is commonly downregulated in LUAD, making it a key target for therapeutic intervention. Our study reveals that SAN significantly inhibits LUAD. Mechanistically, SAN bound to Large Tumor Suppressor 1 (LATS1) and promoted its phosphorylation, thereby activating the Hippo pathway and pyroptosis in LUAD. Notably, YAP overexpression inhibited pyroptosis and weakened the antitumor effect of SAN, further confirming that SAN exerts its antitumor effects by regulating the Hippo-YAP axis. Findings from both

Indexed as

Adenocarcinoma of LungBenzophenanthridinesIsoquinolinesLung NeoplasmsPyroptosisTumor MicroenvironmentAnimalsCell Line, TumorHippo Signaling PathwayHumansMiceProtein Serine-Threonine KinasesSignal TransductionBenzophenanthridinesIsoquinolinesProtein Serine-Threonine KinasessanguinarineHippo signaling pathwayLUADpyroptosissanguinarinetumor immune microenvironment

Identifiers

PMID42910301
PMCPMC13686061

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.