ArticleReports of biochemistry & molecular biology2025
Protective Effect of Naringenin on Cisplatin-Induced Liver Toxicity via Suppressing Inflammation and Oxidative Stress in Mice.
Article in Reports of biochemistry & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cisplatin (Cis) is a chemotherapeutic drug recognized for its hepatotoxic effects and its potential to trigger oxidative stress. This research aimed to evaluate the protective function of naringenin (NG) in mitigating Cis-induced liver toxicity by examining the inflammatory pathways and oxidative stress in mice. Methods: Adult male mice were given 50 mg/kg NG for two weeks, without Cis or with 10 mg/kg Cis on the 10th day. Histological analysis and biochemical indicators, including AST (Aspartate aminotransferase), ALT (Alanine aminotransferase), and ALP (Alkaline phosphatase), were measured to evaluate liver toxicity. The protein levels of Nrf2 (Nuclear factor erythroid 2-related factor 2) and NF-κB (nuclear factor-kappa B), two main inflammation-related biomarkers, were measured to assess inflammation within the liver tissue. Oxidative stress biomarkers, including CAT (Catalase), GSH (Glutathione), SOD (Superoxide dismutase), and MDA (Malondialdehyde), were also evaluated. Results: Pretreatment with NG improved histological changes and decreased AST, ALT, and ALP levels, indicating the attenuating impact of NG against liver toxicity induced by Cis. NG reduced inflammation of the liver tissue by decreasing Nrf2 protein levels and elevating the levels of NF-κB protein in the Cis-intoxicated mice. NG could also suppress oxidative stress in the liver tissue of the Cis-treated mice via decreasing MDA contents and enhancing CAT, SOD, and GSH levels. Conclusions: The findings indicated that NG exerts a protective action against Cis-induced hepatotoxicity by reducing histological alterations, inflammation, and oxidative stress.
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