Evidence map›Paper›PMID 42910259›Full record

ArticleInternational journal of biological sciences2026

Young plasma-derived exosomes deliver YOD1 to induce M2 polarization and ameliorate osteoporosis via mTOR signaling pathways.

Jiahao Wang, Xiaokang Zhang, Siteng Li, Qi Zhang, Jiheng Xiao, Chengbin Huang, Jianpeng Chen, Yang Luo, Zeming Shan, Ziping Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
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Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiahao WangNankai University School of Medicine, Tianjin, China.
Xiaokang ZhangDepartment of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
Siteng LiNankai University School of Medicine, Tianjin, China.
Qi ZhangDepartment of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
Jiheng XiaoDepartment of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
Chengbin HuangDepartment of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
Jianpeng ChenNankai University School of Medicine, Tianjin, China.
Yang LuoDepartment of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
Zeming ShanDepartment of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
Ziping ChenDepartment of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
Ling WangDepartment of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China.
Yingze ZhangNankai University School of Medicine, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the therapeutic potential of young plasma-derived exosomes (Y-Exos) in osteoporosis, focusing on their capacity to modulate macrophage polarization and bone homeostasis. Ovariectomized (OVX) mice were administered young plasma, aged plasma, exosome-depleted plasma, or plasma-derived exosomes. Bone mass, macrophage polarization, and osteoblast/osteoclast activity were analyzed by micro-CT, flow cytometry, and histology. Human Y-Exos were isolated to examine their direct effects on BMSC osteogenesis and BMM polarization, as well as indirect effects on osteoclastogenesis. Proteomic and transcriptomic approaches were employed to identify key functional proteins and underlying mechanisms. For results, young plasma significantly improved bone mass, increased CD206

Indexed as

ExosomesOsteoporosisTOR Serine-Threonine KinasesAnimalsFemaleHumansMacrophagesMesenchymal Stem CellsMiceMice, Inbred C57BLOsteoclastsOsteogenesisOvariectomySignal TransductionTOR Serine-Threonine Kinasesmacrophage polarizationmTOR signaling pathwayosteoporosisYOD1young plasma-derived exosomes

Identifiers

PMID42910259
PMCPMC13685755

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.