ArticleInternational journal of biological sciences2026
LDHA Lactylation Drives Malignant Progression of Oral Squamous Cell Carcinoma via a Positive Feedback Loop with Lactate.
Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Lysine lactylation (Kla) is an emerging post-translational modification closely linked to glycolysis, where it functions to regulate the activity of glycolytic enzymes. In oral squamous cell carcinoma (OSCC), elevated expression of Lactate dehydrogenase A (LDHA) drives lactate production, thereby supplying the substrate for Kla. Nevertheless, whether LDHA itself undergoes Kla in OSCC has yet to be explored. Here, we have conclusively verified that LDHA undergoes high-level Kla in OSCC tissues and cells, with its Kla abundance positively associated with intracellular lactate concentrations. Both
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