Evidence map›Paper›PMID 42910182›Full record

ArticleBioactive materials2027

Oxygen-vacancy-rich LDH sonosensitizers potentiate narrow-spectrum antibiotics via membrane-disruption strategy for mixed bacterial wound infections.

Licheng Xi, Xue Liu, Chaojie Yu, Tao Wang, Junyu Liao, Yanghua Lv, Mian Zhang, Yajie Zhang, Tingting Hu, Ruizheng Liang and 1 more

Abstract read
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In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Licheng XiDepartment of Orthopaedics, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, PR China.
Xue LiuDepartment of Orthopaedics, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, PR China.
Chaojie YuDepartment of Electrical Engineering, City University of Hong Kong, Hong Kong SAR, PR China.
Tao WangState Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Junyu LiaoDepartment of Orthopaedics, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, PR China.
Yanghua LvDepartment of Orthopaedics, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, PR China.
Mian ZhangDepartment of Orthopaedics, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, PR China.
Yajie ZhangState Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Tingting HuDepartment of Electrical Engineering, City University of Hong Kong, Hong Kong SAR, PR China.
Ruizheng LiangState Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Chong ShenDepartment of Orthopaedics, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mixed bacterial infections, including Gram-positive and Gram-negative pathogens, remain a major global health concern. Achieving efficient treatment of synergistic polymicrobial infections stills a tremendous clinical challenge due to antibiotic permeability barriers and resistance. Here, we construct a defect-engineered layered double hydroxide (LDH)-based sonosensitizer platform loaded with clindamycin (a-CoW/CLD) for mixed bacterial infection therapy, which not only demonstrates high efficacy against Gram-positive bacteria, but also exploits reactive oxygen species (ROS)-mediated membrane disruption of Gram-negative bacteria to facilitate CLD penetration, thereby achieving broad-spectrum and highly efficient killing of mixed bacteria. The amorphous a-CoW nanosheets, enriched with oxygen vacancies via acid etching, exhibit a substantially narrowed bandgap (1.22 eV) and markedly enhanced charge separation, producing 22.1-fold higher singlet oxygen under ultrasound (US) irradiation compared with pristine CoW. This ROS burst synergized with CLD achieves potent killing of

Indexed as

Antibiotic synergyDefect engineeringLayered double hydroxideMixed bacterial infectionSonodynamic therapy

Identifiers

PMID42910182
PMCPMC13685460

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.