Fundamental investigation of sustained and controlled therapeutics release from 3D printed medical devices.

R Janusziewicz, R Shrivastava, D K Dahl, I C Young, M Bis, A N Whitesell, S R Benhabbour

Abstract read

In one paragraph

Article in Materials today. Chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

R JanusziewiczJoint Department of Biomedical Engineering, North Carolina State University and the University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

R ShrivastavaJoint Department of Biomedical Engineering, North Carolina State University and the University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

D K DahlJoint Department of Biomedical Engineering, North Carolina State University and the University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

I C YoungDivision of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

M BisJoint Department of Biomedical Engineering, North Carolina State University and the University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

A N WhitesellDivision of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

S R BenhabbourJoint Department of Biomedical Engineering, North Carolina State University and the University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

Next Generation Multipurpose Intravaginal Ring Technology Using Innovative CLIP 3D PrintingR01AI150358 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENHABBOUR, SOUMYA RAHIMA · 2020 to 2024

$4.1M

NIAID NIH HHS R01 AI150358

6 · The paper itself

Abstract

Additive manufacturing has long been acclaimed as the tool for next-generation drug delivery device production. An ongoing challenge has remained with the best method of therapeutic incorporation into these devices as the layering mechanisms associated with 3D printing can be harsh and incompatible with most drugs of interest. We propose a method of post-fabrication absorption, or post-loading, of a silicone-based matrix fabricated with digital light synthesis (DLS). The fundamental mechanisms of this process were investigated using a simplified system of blocks with varied diffusion distances. We determined the critical role of specific surface area in the swelling, uptake, and

Indexed as

3D printingAbsorptionDigital light synthesis (DLS)Intravaginal ring (IVR)Post-loadingSustained delivery

Identifiers

PMID42910150

DOI10.1016/j.mtchem.2022.100978

PMCPMC13685425

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.