Evidence map›Paper›PMID 42910121›Full record

ArticleMolecular therapy. Advances2026

DNA ejection and AAV capsid degradation under thermal stress: Insights from CDMS and native digestion strategies.

Chen Du, Shuli Tang, Song Nie, Yuetian Yan, Victoria C Cotham, Wen Shi, Yan Zhao, Kuan-Yu Lai, Li Zhi, Lin Luo and 10 more

Abstract read
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Chen DuAnalytical and Biological Mass Spectrometry, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Shuli TangAnalytical and Biological Mass Spectrometry, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Song NieAnalytical and Biological Mass Spectrometry, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Yuetian YanAnalytical and Biological Mass Spectrometry, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Victoria C CothamAnalytical and Biological Mass Spectrometry, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Wen ShiDrug Product Development and Technology, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Yan ZhaoDrug Product Development and Technology, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Kuan-Yu LaiDrug Product Development and Technology, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Li ZhiDrug Product Development and Technology, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Lin LuoDrug Product Development and Technology, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Yuan CaoDrug Product Development and Technology, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Serena WangDrug Product Development and Technology, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Dingjiang LiuDrug Product Development and Technology, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Mohammed ShameemDrug Product Development and Technology, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Glynn O'GradyProduct Biochemistry, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Nina LiuProduct Biochemistry, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Michael P RosconiProduct Biochemistry, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Erica A PylesProduct Biochemistry, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Shunhai WangAnalytical and Biological Mass Spectrometry, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Ning LiAnalytical and Biological Mass Spectrometry, Regeneron Pharmaceutical Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adeno-associated viruses (AAVs) are the predominant vectors for

Indexed as

AAVadeno-associated viruscapsid degradationCDMScharge detection mass spectrometryDNA-protein aggregationgenome ejectionnative enzymatic digestionthermal stabilityviral protein externalization

Identifiers

PMID42910121
PMCPMC13685436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.