Evidence map›Paper›PMID 42910103›Full record

ArticleGenes & diseases2027

Activation of AIM2 inflammasome cascade by extracellular trap-laden neutrophil vesicles triggered by

Linwei Xiang, Yuqing Zhao, Yaqian Duan, Jia Xu, Yan You, Xuehua Kong, Jianbo Zhang, Rui Wu, Lan Zhou, Liang Duan

Abstract read
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In one paragraph

Article in Genes & diseases, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Linwei XiangKey Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
Yuqing ZhaoKey Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
Yaqian DuanDepartment of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Jia XuKey Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
Yan YouDepartment of Pathology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Xuehua KongDepartment of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Jianbo ZhangDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Rui WuDepartment of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Lan ZhouKey Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
Liang DuanDepartment of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophil dysfunction and activation of the absent in melanoma 2 (AIM2) inflammasome have been implicated in ulcerative colitis (UC) pathogenesis. However, whether these two immune responses interact synergistically and their precise role in UC remains unclear. Here, we performed bioinformatics and clinical analyses to assess neutrophil extracellular traps (NETs) and AIM2 inflammasome cascades in UC, including their correlation. Dual immunofluorescence revealed the predominant cell types expressing AIM2. Neutrophil activation and NETs release were examined in

Indexed as

AIM2 inflammasomeExtracellular vesiclesNETsPyroptosisUlcerative colitis

Identifiers

PMID42910103
PMCPMC13684999

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.