Evidence map›Paper›PMID 42910091›Full record

ArticleBioactive materials2027

Janus-structured piezoelectric membrane couples barrier protection with pathological microenvironment-responsive bioactivity for periodontal bone regeneration.

Changxu Chen, Jianfeng Sun, Kun Fang, Wei Miao, Xinhong Du, Jiaxuan Li, Xiaozhou Wen, Zhipeng Qu, Engui Wang, Han Ouyang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Changxu ChenBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.
Jianfeng SunBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.
Kun FangBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.
Wei MiaoBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.
Xinhong DuSchool of Biomedical Engineering, Tsinghua University, Beijing, 100084, China.
Jiaxuan LiBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.
Xiaozhou WenBeijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.
Zhipeng QuSchool of Nanoscience and Engineering, School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 101408, China.
Engui WangSchool of Nanoscience and Engineering, School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 101408, China.
Han OuyangSchool of Nanoscience and Engineering, School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 101408, China.
Meng XiaoVita Tech Innovation Center, Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 100084, China.
Shuncheng YaoVita Tech Innovation Center, Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 100084, China.
Lin WangDepartment of Stomatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Xi CuiVita Tech Innovation Center, Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 100084, China.
Zhou LiVita Tech Innovation Center, Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 100084, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontal bone regeneration remains challenging due to the persistent infection-inflammation-bone resorption cycle and the rapid invasion of epithelial and gingival connective tissues into defect sites. Here, we developed a biodegradable Janus membrane (J-PLLA-ZnO) based on poly(L-lactic acid) (PLLA) that spatially integrates barrier protection and pH-responsive bioactivity within a single construct. A dense PLLA layer facing soft tissues prevents premature tissue infiltration and maintains regenerative space, while a porous defect-facing interface functionalized with ZnO nanowires provides bioactive regulation. The ZnO nanowires enhance the overall piezoelectric response of the membrane and enable pH-responsive Zn

Indexed as

BiodegradablePeriodontitisPiezoelectricZinc oxide nanowires

Identifiers

PMID42910091
PMCPMC13685001

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.