Evidence map›Paper›PMID 42910079›Full record

ReviewEuropean heart journal open2026

Digital technology-enabled healthcare services and cardiovascular outcomes in patients with cardiovascular disease: a systematic review and meta-analysis.

Masanari Kuwabara, Tetsuo Yamaguchi, Ayako Harima, Chinatsu Komiyama, Takayoshi Kanie, Atsushi Mizuno, Ken Kozuma, Takahide Kodama

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Masanari KuwabaraDepartment of Cardiology, Toranomon Hospital, 2-2-2, Toranomon, Minato, Tokyo 105-8470, Japan.ORCID https://orcid.org/0000-0002-6601-4347
Tetsuo YamaguchiDepartment of Cardiology, Toranomon Hospital, 2-2-2, Toranomon, Minato, Tokyo 105-8470, Japan.ORCID https://orcid.org/0000-0002-9641-4894
Ayako HarimaDepartment of Cardiology, Toranomon Hospital, 2-2-2, Toranomon, Minato, Tokyo 105-8470, Japan.
Chinatsu KomiyamaDepartment of Cardiology, Toranomon Hospital, 2-2-2, Toranomon, Minato, Tokyo 105-8470, Japan.ORCID https://orcid.org/0009-0007-6512-1881
Takayoshi KanieDivision of Cardiology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada.ORCID https://orcid.org/0000-0002-6955-0671
Atsushi MizunoDepartment of Cardiology, St. Luke's International Hospital, 9-1, Akashi-cho, Chuo, Tokyo 104-8560, Japan.ORCID https://orcid.org/0000-0002-7596-7633
Ken KozumaDivision of Cardiology, Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1, Kaga, Itabashi, Tokyo 173-8606, Japan.ORCID https://orcid.org/0000-0003-3977-5973
Takahide KodamaDepartment of Cardiology, Toranomon Hospital, 2-2-2, Toranomon, Minato, Tokyo 105-8470, Japan.ORCID https://orcid.org/0000-0002-7029-1881

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Digital technology-enabled healthcare services may support secondary prevention in patients with cardiovascular disease; however, their effects on clinical outcomes remain uncertain. We performed a systematic review and meta-analysis to evaluate their impact on cardiovascular outcomes. PubMed and Embase were searched from inception to 11 March 2025. Randomized controlled trials evaluating digital technology-enabled healthcare services in patients with established cardiovascular disease were included. The primary outcome was major adverse cardiovascular and cerebrovascular events (MACCE), as defined in each trial. Secondary outcomes included rehospitalization, coronary artery disease-related events, all-cause mortality, cardiovascular mortality, revascularization, and adverse events. The protocol was registered in PROSPERO (CRD420251186138) Among 3603 records identified, 14 randomized controlled trials were included. Digital technology-enabled healthcare services were associated with a reduced risk of MACCE (risk ratio 0.595; 95% confidence interval 0.471-0.752;

Indexed as

Cardiovascular diseaseDigital healthMajor adverse cardiovascular and cerebrovascular events (MACCE)Meta-analysisSecondary prevention

Identifiers

PMID42910079
PMCPMC13684969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.