Evidence map›Paper›PMID 42910076›Full record

ReviewAquaculture nutrition2026

Dietary Butyrate as a Functional Feed Additive in Aquaculture: A Systematic Review and Meta-Analysis of Immunological and Antioxidant Responses With Dose-Response Insights.

Moussa Gouife, Tchouli Noufeu, Yubin Chen, Xiwen Jia, Jiajie Xu

Abstract readReview
In one paragraph

Review in Aquaculture nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Moussa GouifeMicrobial Development and Metabolic Engineering Laboratory School of Marine Science Ningbo University Ningbo 315211 China nbu.edu.cn.ORCID https://orcid.org/0009-0004-8355-8751
Tchouli NoufeuNational Higher School of Agriculture Fisheries and Veterinary Medicine (ENSAHV) University of Douala Douala Cameroon univ-douala.cm.ORCID https://orcid.org/0009-0003-0226-2522
Yubin ChenMicrobial Development and Metabolic Engineering Laboratory School of Marine Science Ningbo University Ningbo 315211 China nbu.edu.cn.
Xiwen JiaMicrobial Development and Metabolic Engineering Laboratory School of Marine Science Ningbo University Ningbo 315211 China nbu.edu.cn.ORCID https://orcid.org/0000-0002-8667-8482
Jiajie XuMicrobial Development and Metabolic Engineering Laboratory School of Marine Science Ningbo University Ningbo 315211 China nbu.edu.cn.ORCID https://orcid.org/0000-0002-3931-4766

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aquaculture intensification has increased the demand for nutritional strategies that support immune responses and oxidative balance in cultured finfish and crustaceans, thereby reducing disease susceptibility and improving production stability. Butyrate, a short-chain fatty acid increasingly incorporated into aquafeeds as a functional feed additive, has shown promise in enhancing immune responses and antioxidant defenses, but reported effects vary widely across species, life stages, and supplementation levels. This systematic review and meta-analysis synthesizes findings from 65 studies (1174 dose-control comparisons) across 23 aquaculture species to assess butyrate's effects on innate and adaptive immunity, oxidative stress, and antioxidant capacity. Dietary butyrate generally enhanced innate immune responses (

Indexed as

antioxidant capacitybutyratedose–response modelingfunctional feed additiveimmune responsesmeta‑analysis

Identifiers

PMID42910076
PMCPMC13686364

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.