ArticleFrontiers in pharmacology2026
Quercetin upregulates TLE4 to block the Wnt/β-catenin signaling pathway and inhibit cell migration and invasion of cervical cancer cells.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methods: Using established TLE4-overexpression and CRISPR-Cas9-knockout cervical cancer cell lines and nude mouse tumorigenesis models, we verified the biological function and regulatory mechanism of TLE4 in cervical cancer. Results: Quercetin treatment upregulated the expression of TLE4 in HeLa cells. Compared with normal cervical tissues from clinical specimens, the expression of TLE4 in the nucleus of cervical cancer tissues was significantly downregulated. Transwell assays showed that the migration and invasion of C-33A TLE4-overexpression cells were significantly suppressed, accompanied by an upregulation of the expression of E-cadherin and a downregulation of the expression of N-cadherin, Vimentin, and Snail. Conversely, the migration and invasion of Ca Ski TLE4-knockout cells were significantly enhanced, and the expressions of these EMT-related markers showed the opposite trend. Meanwhile, the Conclusion: Quercetin targets and upregulates the expression of TLE4, which inhibits the migration and invasion of cervical cancer cells by blocking the Wnt/β-catenin signaling pathway, thereby providing theoretical and experimental evidence for quercetin therapy in cervical cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.