Evidence map›Paper›PMID 42910035›Full record

ArticleRSC medicinal chemistry2026

Design, synthesis, and

Valeria Pittalà, Loredana Salerno, Valeria Consoli, Agata Grazia D'Amico, Valeria Sorrenti, Luca Vanella, Giorgia Centamore, Chiara Terlati, Sara Mocka, Maria Nunziata Modica and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Valeria PittalàDepartment of Drug and Health Sciences, University of Catania viale A. Doria 6 95125 Catania Italy s.intagliata@unict.it +39 095 738 4053.
Loredana SalernoDepartment of Drug and Health Sciences, University of Catania viale A. Doria 6 95125 Catania Italy s.intagliata@unict.it +39 095 738 4053.ORCID https://orcid.org/0000-0001-6458-3717
Valeria ConsoliDepartment of Drug and Health Sciences, University of Catania viale A. Doria 6 95125 Catania Italy s.intagliata@unict.it +39 095 738 4053.ORCID https://orcid.org/0000-0001-8961-5818
Agata Grazia D'AmicoDepartment of Drug and Health Sciences, University of Catania viale A. Doria 6 95125 Catania Italy s.intagliata@unict.it +39 095 738 4053.ORCID https://orcid.org/0000-0003-4216-417X
Valeria SorrentiDepartment of Drug and Health Sciences, University of Catania viale A. Doria 6 95125 Catania Italy s.intagliata@unict.it +39 095 738 4053.ORCID https://orcid.org/0000-0002-5973-1495
Luca VanellaDepartment of Drug and Health Sciences, University of Catania viale A. Doria 6 95125 Catania Italy s.intagliata@unict.it +39 095 738 4053.ORCID https://orcid.org/0000-0002-6314-6029
Giorgia CentamoreDepartment of Drug and Health Sciences, University of Catania viale A. Doria 6 95125 Catania Italy s.intagliata@unict.it +39 095 738 4053.
Chiara TerlatiDepartment of Drug and Health Sciences, University of Catania viale A. Doria 6 95125 Catania Italy s.intagliata@unict.it +39 095 738 4053.
Sara MockaDepartment of Drug and Health Sciences, University of Catania viale A. Doria 6 95125 Catania Italy s.intagliata@unict.it +39 095 738 4053.ORCID https://orcid.org/0009-0005-5060-0965
Maria Nunziata ModicaDepartment of Drug and Health Sciences, University of Catania viale A. Doria 6 95125 Catania Italy s.intagliata@unict.it +39 095 738 4053.ORCID https://orcid.org/0000-0002-6350-931X
Giuseppe RomeoDepartment of Drug and Health Sciences, University of Catania viale A. Doria 6 95125 Catania Italy s.intagliata@unict.it +39 095 738 4053.ORCID https://orcid.org/0000-0003-2160-4164
Marica Erminia SchianoDepartment of Pharmacy, "Federico II" University of Naples 80131 Naples Italy.ORCID https://orcid.org/0000-0002-4456-3003
Federica SodanoDepartment of Pharmacy, "Federico II" University of Naples 80131 Naples Italy.ORCID https://orcid.org/0000-0003-2013-4893
Mohamed A HelalBiomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology Giza 12587 Egypt.ORCID https://orcid.org/0000-0002-6304-8285
Sebastiano IntagliataDepartment of Drug and Health Sciences, University of Catania viale A. Doria 6 95125 Catania Italy s.intagliata@unict.it +39 095 738 4053.ORCID https://orcid.org/0000-0002-0201-1745

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, dasatinib (DASA) and heme oxygenase-1 (HO-1) inhibitor codrugs were designed and synthesized. Derivatization of DASA was performed by preserving the structural features essential for target inhibition and was rationally guided by molecular modelling studies. Two out of three synthesized codrugs showed the ability to inhibit HO-1 activity in a low micromolar range (

Identifiers

PMID42910035
PMCPMC13684878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.