ReviewCureus2026
Chronic Complications Following Dengue Infection: A Scoping Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue virus infection has increased substantially in Latin America, prompting epidemiological alerts from regional health authorities in recent years. While most published research focuses on the acute phase, chronic multisystemic sequelae remain poorly characterized. This scoping review aimed to identify and describe chronic complications in adult patients following dengue infection, as reported in the available scientific literature. A scoping review was conducted following the PRISMA-ScR guidelines. A structured Population, Concept, Context (PCC) question guided searches of PubMed (National Library of Medicine, Bethesda, Maryland), Scopus (Elsevier, Amsterdam, the Netherlands), Google Scholar (Google, Mountain View, California), EMBASE (Elsevier, Amsterdam, the Netherlands), Cochrane Library (John Wiley & Sons, Hoboken, New Jersey), and LILACS (BIREME, São Paulo, Brazil), and gray literature from January 2005 to June 15, 2026. Articles were screened independently by eight reviewers using Rayyan; inter-rater reliability was assessed using Fleiss' kappa (κ = 0.81, 95% CI: 0.74-0.88), and disagreements were resolved by consensus. Of the 222 identified records, 62 studies met the inclusion criteria after deduplication and full-text screening. Neurological complications were the most frequently represented category among the included publications (30.6%, n = 19), followed by ophthalmological (19.4%, n = 12), heterogeneous persistent symptoms (12.9%, n = 8), fatigue (9.7%, n = 6), multisystemic (9.7%, n = 6), psychiatric (9.7%, n = 6), cardiological (4.8%, n = 3), and immunological (3.2%, n = 2) complications. These proportions reflect the distribution of the published literature rather than the clinical prevalence of complications among dengue patients, given that approximately one-third of the included studies were case reports or case series. The evidence base includes the largest population-based cohort of post-acute dengue sequelae to date (n = 55,870, Singapore), a two-year disability-adjusted life-year (DALY) burden analysis from the same registry, the first systematic review of dengue-associated Guillain-Barré syndrome, the first reported case of chronic dengue encephalitis with brain-tissue DENV RNA confirmed by metagenomic sequencing, and two narrative reviews that substantially expanded the evidence base on psychiatric sequelae. Dengue infection is associated with a broad and heterogeneous spectrum of chronic complications affecting multiple organ systems, including elevated post-acute cardiovascular, neuropsychiatric, and autoimmune risks, as well as a measurable disease and healthcare cost burden. The absence of a consistent relationship between acute severity and chronic outcomes supports structured, evidence-based, long-term post-dengue follow-up, particularly for patients with persistent symptoms or clinically relevant risk factors and for underrepresented Latin American populations.
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