Evidence map›Paper›PMID 42909956›Full record

ArticleCell biomaterials2026

A long-acting injectable nanoparticle-hydrogel depot enables sustained IGF-1 delivery to reverse chronic denervation.

Yicheng Zhang, Thomas G W Harris, Christopher J Erb, Chenhu Qiu, Karim A Sarhane, Philip Hanwright, Benjamin R Slavin, Zhi-Cheng Yao, Jiayuan Kong, Erica B Lee and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Yicheng ZhangDepartment of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD 21218, USA.
Thomas G W HarrisInstitute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.
Christopher J ErbDepartment of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD 21218, USA.
Chenhu QiuDepartment of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD 21218, USA.
Karim A SarhaneDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Philip HanwrightDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Benjamin R SlavinDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Zhi-Cheng YaoDepartment of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD 21218, USA.
Jiayuan KongDepartment of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD 21218, USA.
Erica B LeeDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Nicholas von GuionneauDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jeffrey KhongDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Rachana SureshDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Dany Y MatarDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Alexander J TinanaDepartment of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD 21218, USA.
Moonhyung LeeDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Marcos IglesiasDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Connor GlassDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Nicholas HriczDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Sai PinniDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Matthew GenerosoDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Visakha SureshDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Aysel Cetinkaya-FisginDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Eric K HutchinsonDepartment of Molecular and Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jessica IzziDepartment of Molecular and Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kara SegnaDepartment of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Sashank ReddyInstitute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.
Ahmet HökeDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Hai-Quan MaoDepartment of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD 21218, USA.
Sami H TuffahaDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Funding

Long-acting Injectable Protein Delivery System for Functional Repair of Peripheral Nerve InjuryR01NS134925 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Hai-Quan Mao, Sami Tuffaha · 2024 to 2026
$1.7M
NINDS NIH HHS R01 NS134925
6 · The paper itself

Abstract

Chronic denervation following peripheral nerve injury leads to progressive muscle atrophy and Schwann cell dysfunction that severely limit functional recovery, yet no therapies effectively sustain trophic support over the prolonged regenerative period. Here, we develop a long-acting injectable (LAI) biomaterial platform that enables sustained local delivery of insulin-like growth factor-1 (IGF-1). The system encapsulates IGF-1 in poly(ethylene glycol)-

Identifiers

PMID42909956
PMCPMC13685680

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.