ArticleClinical neuropsychiatry2026
Psychiatric Comorbidity Outweighs Headache Subtype As A Predictor Of Disability In Chronic Daily Headache: A Matched-Control Study.
Article in Clinical neuropsychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Objective: Chronic daily headache (CDH) is a prevalent neuropsychiatric condition. We aimed to quantify concurrent Axis I psychiatric comorbidity and personality pathology in CDH versus matched controls and identify factors independently associated with headache-related disability. Method: This hospital-based matched-control study was conducted at a tertiary teaching hospital in Faridabad (Delhi-NCR), India. Seventy-five ICHD-3-confirmed CDH patients and 75 age- and sex-matched controls completed the Mini International Neuropsychiatric Interview (MINI v5.0), Millon Clinical Multiaxial Inventory-III (MCMI-III; personality, base rate ≥ 85), and Headache Impact Test-6 (HIT-6). Multivariable binary logistic regression identified independent cross-sectional associates of high disability (HIT-6 ≥ 56). STROBE guidelines were followed. Results: Psychiatric comorbidity was present in 60.0% of cases versus 13.3% of controls (χ Conclusions: Psychiatric comorbidity was strongly and independently associated with disability in CDH, supporting integrated psychiatric screening. The exploratory Cluster A signal warrants replication in adequately powered prospective studies.
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