Evidence map›Paper›PMID 42909904›Full record

ArticleBrain communications2026

Alzheimer's disease risk gene

Hannah J Lucas-Clarke, Daniel C Maddison, Leonardo Amadio, Edgar Buhl, Clement Regnault, Owen M Peters, James J L Hodge, Gaynor A Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hannah J Lucas-ClarkeDivision of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF24 4HQ, UK.
Daniel C MaddisonDivision of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF24 4HQ, UK.
Leonardo AmadioDivision of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF24 4HQ, UK.
Edgar BuhlSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1QU, UK.
Clement RegnaultShared Research Facilities, College of Medical Veterinary Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Owen M PetersUK Dementia Research Institute at Cardiff University, School of Medicine, Cardiff CF24 4HQ, UK.ORCID https://orcid.org/0000-0002-6824-0663
James J L HodgeSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1QU, UK.
Gaynor A SmithDivision of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff CF24 4HQ, UK.ORCID https://orcid.org/0000-0003-4332-8383

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies have identified multiple loci that contribute to late-onset Alzheimer's disease risk, yet the functional mechanisms of many candidate genes remain unclear. WW-domain containing oxidoreductase (

Indexed as

Alzheimer’s diseaseamyloidDrosophilarisk genesWWOX

Identifiers

PMID42909904
PMCPMC13684411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.