Evidence map›Paper›PMID 42909893›Full record

ArticleInternational journal of medical sciences2026

Epigenome-Wide DNA Methylation Profiling of Matched Primary Breast Cancers and Brain Metastases Reveals Epigenetic Markers linked to Metastatic Progression: A Preliminary Study.

Beate Alinger-Scharinger, Georg Hutarew, Christoph Schwartz, Alexander Romagna, Ognian Kalev, Serge Weis, Simon P Gampenrieder, Gabriel Rinnerthaler, Vanessa Castagnaviz, Franz Gassner and 5 more

Abstract read
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In one paragraph

Article in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Beate Alinger-ScharingerInstitute of Pathology, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstr. 48, A-5020 Salzburg, Austria.
Georg HutarewInstitute of Pathology, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstr. 48, A-5020 Salzburg, Austria.
Christoph SchwartzDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Alexander RomagnaDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Ognian KalevDivision of Neuropathology, Neuromed Campus, Institute of Pathology and Molecular Pathology, Kepler University Hospital, Johannes Kepler University, Linz, Austria and Clinical Research Institute for Neurosciences, Johannes Kepler University Linz, Austria.
Serge WeisDivision of Neuropathology, Neuromed Campus, Institute of Pathology and Molecular Pathology, Kepler University Hospital, Johannes Kepler University, Linz, Austria and Clinical Research Institute for Neurosciences, Johannes Kepler University Linz, Austria.
Simon P GampenriederClinic of Internal Medicine 3, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Gabriel RinnerthalerClinic of Internal Medicine 3, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Vanessa CastagnavizClinic of Internal Medicine 3, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Franz GassnerClinic of Internal Medicine 3, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Roland GeisbergerClinic of Internal Medicine 3, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Nadja ZaborskyClinic of Internal Medicine 3, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Richard GreilClinic of Internal Medicine 3, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Karl SotlarInstitute of Pathology, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstr. 48, A-5020 Salzburg, Austria.
Theo F J KrausInstitute of Pathology, University Hospital Salzburg, Paracelsus Medical University, Müllner Hauptstr. 48, A-5020 Salzburg, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Breast cancer represents the most prevalent malignancy among women globally, with a rising incidence of metastases to the central nervous system. The presence of brain metastases is associated with a poor prognosis, largely due to the limited availability of effective treatment modalities. Methods: In this preliminary study, we performed an epigenome-wide DNA-methylation analysis of matched primary breast cancer and brain metastasis of the same patients applying the Illumina Infinium EPIC Bead Chip interrogating more than 850,000 CpG sites at single base resolution. Results: We found that primary breast cancers and corresponding metastases are very similar on the global DNA methylation level. Detailed analysis showed aberrant methylation patterns that reflect the process of brain metastasis. We identified 107 nominally significant methylated CpG sites (DMCGs) within promoter and gene regions (Δβ ≥ 0.1, Conclusion: Our study highlights specific aberrant DNA methylation patterns that are associated with brain metastasis in breast cancer. Characterizing these epigenetic alterations provides a promising avenue for identifying novel therapeutic targets and clinically relevant biomarkers.

Indexed as

Biomarkers, TumorBrain NeoplasmsBreast NeoplasmsDNA MethylationEpigenomeAdultCpG IslandsDisease ProgressionEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedPromoter Regions, GeneticBiomarkers, Tumorbrain metastasesbreast cancerepigenetic profilingmetastasismethylome

Identifiers

PMID42909893
PMCPMC13685463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.