Enzymatic cross-linking collagen-based bioink for 3D bioprinting of endometrial model with endometrial epithelial organoids.

Huimin Shi, Xin Xu, Qingru Huang, Mengying Liu, Xuechai Bai, Yana Ma, Yifan Wang, Xiaona Lin, Jun Yin

Abstract read

In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Huimin ShiThe State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.

Xin XuDepartment of Gynecology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, 310008, China.

Qingru HuangThe State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.

Mengying LiuDepartment of Gynecology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, 310008, China.

Xuechai BaiDepartment of Gynecology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, 310008, China.

Yana MaAssisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.

Yifan WangDepartment of General Surgery, Sir Run Run Shaw Hospital Affiliated to School of Medicine, Zhejiang University, Hangzhou, 310016, China.

Xiaona LinDepartment of Gynecology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, 310008, China.

Jun YinThe State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human endometrium, a dynamic tissue responsive to sex hormones, plays a pivotal role in female reproduction and menstrual cycling, comprising diverse cell populations including epithelial and stromal cells. The development of in vitro endometrial models holds substantial potential for tissue repair, drug discovery, and disease modeling. However, the construction of biomimetic structural in vitro models capable of supporting long-term culture and preserving relevant biological functions has been hindered by limitations in both material properties and fabrication strategies. Here, an enzymatically cross-linked collagen-based bioink was developed, enabling extrusion bioprinting with favorable printability, biocompatibility, and bioactivity. The enzyme-catalyzed cross-linking process was optimized through room-temperature pre-crosslinking, and its evolution was described using a storage modulus (

Indexed as

3D bioprintingCollagen bioinkIn vitro endometrial modelOrganoids

Identifiers

PMID42909879

DOI10.1016/j.bioactmat.2026.10.017

PMCPMC13685455

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.