Evidence map›Paper›PMID 42909866›Full record

ReviewTheranostics2026

Ultrasound-induced luminescence imaging for deep tissues.

Qiuyu Cheng, Jinlan Luo, Yandi Tan, Tong Xu, Yufeng Sun, Rui Geng, Hanbin Xu, Xiangmin Zhang, Lingwen Ding, Gege Wu and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qiuyu ChengDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, Hubei Province, 430030, China.
Jinlan LuoDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, Hubei Province, 430030, China.
Yandi TanDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, Hubei Province, 430030, China.
Tong XuDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, Hubei Province, 430030, China.
Yufeng SunHubei Key Laboratory of Bioinorganic Chemistry and Materia Medica; Hubei Engineering Research Center for Biomaterials and Medical Protective Materials; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Rui GengHubei Key Laboratory of Bioinorganic Chemistry and Materia Medica; Hubei Engineering Research Center for Biomaterials and Medical Protective Materials; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Hanbin XuHubei Key Laboratory of Bioinorganic Chemistry and Materia Medica; Hubei Engineering Research Center for Biomaterials and Medical Protective Materials; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Xiangmin ZhangDepartment of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No. 136, Zhongshan Second Road, Chongqing, 400014, China.
Lingwen DingDepartment of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.
Gege WuDepartment of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.
Xinwu CuiDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, Wuhan, Hubei Province, 430030, China.
Yijing LiuHubei Key Laboratory of Bioinorganic Chemistry and Materia Medica; Hubei Engineering Research Center for Biomaterials and Medical Protective Materials; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultrasound-induced luminescence imaging enables non-invasive and space-constrained luminescent probe activation, thereby overcoming the limited penetration and high background of traditional light-excited imaging. In this review, we summarize recent advances in the area, focusing on three major paradigms: instant ultrasound-induced luminescence, sonoafterglow luminescence, and Off-On switching luminescence, with detailed explanations of their mechanisms. We also explore various strategies to improve luminescent and biological performance. Additionally, we offer a comprehensive overview of biomedical applications in the tumor microenvironment, the immune system, the nervous system and other regions. Moreover, major challenges in clinical translation and prospects are discussed and identified. These advances make ultrasound-induced luminescence a practical route for generating and controlling light in deep tissue, with promise for precise imaging and targeted treatment of deep-seated disease.

Indexed as

LuminescenceLuminescent MeasurementsOptical ImagingAnimalsHumansTumor MicroenvironmentUltrasonographydeep-tissue imagingmechanoluminescencesonoafterglowultrasoundultrasound-induced luminescence

Identifiers

PMID42909866
PMCPMC13684393

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.