ReviewMolecular biomedicine2026
Circadian rhythms in health and disease.
Review in Molecular biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Circadian rhythms, serving as a crucial temporal bridge linking neural activity and pathological biology, are regulated by central pacemaker neurons to maintain cellular homeostasis and coordinate diverse biological processes. Circadian rhythm disruption is closely associated with various diseases, including neurodegenerative disorders, metabolic disorders, and cancer. Circadian rhythms are controlled by core clock genes, such as BMAL1 and CLOCK, modulating numerous physiological processes, encompassing metabolism, immune responses, neural activity, and hormone regulation. Circadian rhythms disruptions arising from shift work, jet lag, or inconsistent sleep schedules are implicated in both the onset and progression of numerous diseases, notably Alzheimer's disease, Parkinson's disease, diabetes, and cardiovascular disease. The article highlights how circadian dysregulation alters cellular processes to potentially accelerate disease progression. Circadian disruption results in impaired immune function, further promoting disease development and resistance to treatment. Potential therapeutic applications based on circadian biology, such as chronotherapy and personalized medicine, are also discussed. Recent technological advances, embodied in wearable devices and omics approaches, are increasingly providing deeper insights into circadian biology. Further unveiling the role of circadian in health and disease opens new avenues for tailoring treatment timing to patients' biological rhythms, thereby enhancing therapeutic outcomes across various diseases. By bridging fundamental circadian mechanisms with clinical pathology, this review provides a roadmap for future chronotherapeutic interventions in precision medicine.
Indexed as
Identifiers
42909824What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.