Evidence map›Paper›PMID 42909811›Full record

ArticleMolecular biomedicine2026

Citrullinated histone H3 and elevated polyamine metabolism gene expression in peripheral blood polymorphonuclear leukocytes as biomarkers for poor immunotherapy response in cancer patients.

Amy Anzovino, Stephanie Kjelstrom, Kathryn Fleck, Margaretha Wallon, Eric T Alexander, Susan K Gilmour

Abstract read
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In one paragraph

Article in Molecular biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amy AnzovinoLankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA, 19096, USA.
Stephanie KjelstromLankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA, 19096, USA.
Kathryn FleckLankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA, 19096, USA.
Margaretha WallonLankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA, 19096, USA.
Eric T AlexanderLankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA, 19096, USA.
Susan K GilmourLankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA, 19096, USA. gilmours@mlhs.org.ORCID http://orcid.org/0000-0001-6228-860X

Funding

Sharpe Strumia Research Foundation (US) SSRF2024-03
6 · The paper itself

Abstract

There is a critical need to identify validated biomarkers that can predict cancer patient outcomes. This study evaluated biomarkers of neutrophil extracellular traps (NETs) and polyamine gene expression in peripheral blood that may correlate with greater risk for poor response to immunotherapy. Peripheral blood collected from cancer patients being treated with chemo/immunotherapy and from healthy volunteers was analyzed for levels of citrullinated histone H3 (Cit H3, a NETosis marker), inflammatory cytokines, and circulating tissue factor positive microparticles (TF

Indexed as

Biomarkers, TumorCitrullinationHistonesImmunotherapyNeoplasmsNeutrophilsPolyaminesAnimalsExtracellular TrapsFemaleHumansMaleMiceMiddle AgedBiomarkers, TumorHistonesPolyaminesBlood biomarkersCancer immunotherapyGlutamineNeutrophil extracellular trapsPolyamines

Identifiers

PMID42909811

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.