Evidence map›Paper›PMID 42909796›Full record

ArticleBioresources and bioprocessing2026

Base editing-mediated exon-specific knockout of glutamine synthetase generates a high-productivity CHO cell line for antibody manufacturing.

Tianting Pu, Chengcheng Wang, Hui Lou, Ye Mi, Saiyi Zhang, Siyu Liu, Zhihua Xiao, Qiyao Wang, Qin Liu, Yajing Liu

Abstract read
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In one paragraph

Article in Bioresources and bioprocessing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tianting Pu *State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Chengcheng Wang *State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Hui LouShanghai OPM Biosciences Co. Ltd, Shanghai, 201321, China.
Ye MiState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Saiyi ZhangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Siyu LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Zhihua XiaoShanghai OPM Biosciences Co. Ltd, Shanghai, 201321, China.
Qiyao WangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Qin LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Yajing LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China. liuyajing@ecust.edu.cn.ORCID http://orcid.org/0009-0001-0515-2463

Funding

ECUST-OPM Open Fund 20220701Fundamental Research Funds for the Central University 222201251721Science and Technology Commission of Shanghai Municipality 24HC2820500
6 · The paper itself

Abstract

The Chinese hamster ovary (CHO) cell platform dominates recombinant protein production, with the glutamine synthetase (GS) system widely used for clonal selection. However, we observed variable performance between two commercial CHO lines (ATCC CHO-K1 and CHOZN

Indexed as

Base editingChinese hamster ovary (CHO) cellGlutamine synthetasePremature termination codon

Identifiers

PMID42909796

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.