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ArticleCEN case reports2026

Delayed diagnosis of MEN1 after kidney transplantation: unrecognized pre-transplant features and implications for clinical practice.

Kaiyo Ichikawa, Shunta Hori, Mitsuru Tomizawa, Kuniaki Inoue, Yasushi Nakai, Makito Miyake, Tatsuo Yoneda

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Article in CEN case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Kaiyo IchikawaDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Shunta HoriDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan. horimaus@gmail.com.ORCID http://orcid.org/0000-0001-9514-9964
Mitsuru TomizawaDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Kuniaki InoueDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Yasushi NakaiDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Makito MiyakeDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Tatsuo YonedaDepartment of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple endocrine neoplasia type 1 (MEN1), characterized by multiglandular endocrine tumors such as hyperparathyroidism (HPT), is an autosomal dominant disorder caused by mutations of the MEN1 gene. In patients with chronic kidney disease (CKD), abnormalities in calcium-phosphate metabolism may obscure this diagnosis, making the recognition of MEN1 challenging. A 68-year-old man with end-stage renal disease underwent an ABO-compatible living-donor kidney transplantation (KT); however, persistent hypercalcemia prompted further evaluation, which revealed recurrent HPT with bilateral parathyroid enlargement. Pre-transplant imaging revealed an adrenal adenoma and a pancreatic tail lesion. Subsequent pituitary magnetic resonance imaging and genetic testing confirmed the diagnosis of MEN1. A retrospective review of the patient's medical history revealed several pre-transplant findings suggestive of MEN1 that had not been recognized. This case highlights that MEN1 may remain unrecognized in KT candidates owing to the occurrence of metabolic abnormalities also associated with CKD. The early recognition of MEN1 in KT candidates with recurrent or multiglandular hyperparathyroidism may improve pre-transplant risk assessment and enable appropriate long-term oncological surveillance.

Indexed as

Kidney Failure, ChronicKidney TransplantationMultiple Endocrine Neoplasia Type 1AgedDelayed DiagnosisHumansHypercalcemiaHyperparathyroidismMagnetic Resonance ImagingMaleHypercalcemiaKidney transplantationMultiple endocrine neoplasia type 1

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.