Evidence map›Paper›PMID 42909749›Full record

ArticleScience China. Life sciences2026

MdRAD5B regulates the chromatin accessibility of MdMYB14 under cold by associating with a transcription factor MdLSD1.

Yi Song, Ziqing Ma, Jieqiang He, Jiale Wen, Rongxin Zhou, Yuzheng Zhang, Junxing Guo, Ningning Bian, Fengwang Ma, Yinpeng Xie and 1 more

Abstract read
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In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yi SongState Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, China.
Ziqing MaState Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, China.
Jieqiang HeState Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, China.
Jiale WenState Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, China.
Rongxin ZhouState Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, China.
Yuzheng ZhangState Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, China.
Junxing GuoState Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, China.
Ningning BianState Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, China.
Fengwang MaState Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, China.
Yinpeng XieState Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, China.
Qingmei GuanState Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple, College of Horticulture, Northwest A&F University, Yangling, 712100, China. qguan@nwsuaf.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RADIATION SENSITIVE 5B (MdRAD5B) has previously been identified as a chromatin remodeler involved in regulating the chromatin accessibility and H3K27me3 modification of genes. However, how RAD5B regulates the chromatin accessibility of target genes remains largely unclear. Here, we find that MdRAD5B positively regulates apple cold tolerance by modulating the expression of cold-responsive genes. Under cold stress, MdRAD5B regulates the expression of cold-responsive genes, including MdMYB14, through its chromatin remodeling function. Further study reveals that the transcription factor LESION SIMULATING DISEASE 1 (MdLSD1) recruits MdRAD5B and reduces the chromatin accessibility of MdMYB14. MdMYB14, a downstream target of MdLSD1 and a negative regulator of cold tolerance, binds to the promoter region of MdCBF3 and inhibits its expression. Additionally, we identified a natural variation, a non-synonymous mutation at position 1,780 of the RAD5B CDS (RAD5B

Indexed as

chromatin accessibilitycold toleranceMdLSD1MdRAD5B

Identifiers

PMID42909749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.