Evidence map›Paper›PMID 42909729›Full record

ArticleCVIR endovascular2026

Who should be considered for prostate artery embolization: revisiting the urologic guidelines based on results from over 300 patients with benign prostatic hyperplasia.

Gabriel M Knight, Ajay Varadhan, Elana Benishay, Delmarie M Rivera-Rodríguez, Kimberly Jenkins, Elias Hohlastos, Riad Salem, Samdeep Mouli

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in CVIR endovascular, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02026908 nacompletednot on this map

Prostatic Artery Embolization (PAE) for Treatment of Signs and Symptoms of Benign Prostatic Hyperplasia (BPH)

TypeinterventionalSponsorNorthwestern UniversityRan2014 to 2023Enrolled45ConditionsBenign Prostatic Hyperplasia (BPH)ArmsProstate Artery Embolization
NCT03052049 nacompletednot on this map

Prostatic Artery Embolization (PAE) for Treatment of Signs and Symptoms of Benign Prostatic Hyperplasia (BPH)

TypeinterventionalSponsorNorthwestern UniversityRan2017 to 2022Enrolled28ConditionsBenign Prostatic Hyperplasia (BPH)ArmsProstate Artery Embolization
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabriel M KnightDepartment of Radiology, Section of Vascular and Interventional Radiology, Northwestern University, Chicago, IL, USA.
Ajay VaradhanDepartment of Radiology, Section of Vascular and Interventional Radiology, Northwestern University, Chicago, IL, USA.
Elana BenishayDepartment of Radiology, Section of Vascular and Interventional Radiology, Northwestern University, Chicago, IL, USA.
Delmarie M Rivera-RodríguezDepartment of Radiology, Section of Vascular and Interventional Radiology, Northwestern University, Chicago, IL, USA.
Kimberly JenkinsDepartment of Radiology, Section of Vascular and Interventional Radiology, Northwestern University, Chicago, IL, USA.
Elias HohlastosDepartment of Radiology, Section of Vascular and Interventional Radiology, Northwestern University, Chicago, IL, USA.
Riad SalemDepartment of Radiology, Section of Vascular and Interventional Radiology, Northwestern University, Chicago, IL, USA.
Samdeep MouliDepartment of Radiology, Section of Vascular and Interventional Radiology, Northwestern University, Chicago, IL, USA. s-mouli@northwestern.edu.ORCID http://orcid.org/0000-0001-8329-4232

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate artery embolization (PAE) has emerged as a minimally invasive therapy which affords improvement in benign prostatic hyperplasia (BPH) symptoms and objective urinary parameters with a favorable adverse event (AE) profile. While PAE was recently included in the American Urological Association (AUA) Guidelines, guidance on its specific use-cases is limited. This study sought to answer remaining questions surrounding the safety and efficacy of PAE across different patient subpopulations where formal guidance for PAE is limited.

methodsThree hundred two patients with BPH underwent PAE. Key baseline characteristics were gathered. Patients were compared from baseline to follow-ups with regards to (1) objective parameters, including maximum urinary flow rate (Q

resultsPAE afforded significant improvement (p < 0.05) in each subjective/objective BPH parameter and sexual function score at nearly all follow-up points. Specifically, IPSS improved by 12.3-13.8 points (52.8-59.2%); IPSS-QoL by 2.3-2.8 points (47.9-58.3%); IIEF by 3.2-5.7 points (15.6-27.8%); PSA by 1.5-2.0 ng/mL (15.6-28.5%); and prostate volume by 16.9%. Twelve (4.0%) AEs were reported; no sexual/severe AEs were observed. PAE was safe and afforded significant improvement in subjective/objective BPH parameters in patients with: prostate volumes ≥ 80 mL; prior BPH surgery/intervention; higher medical comorbidity; pre-procedural catheter-dependent urinary retention; pre-procedural renal insufficiency; and pre-procedural hematuria.

conclusionsPAE improved subjective/objective BPH parameters and sexual function. Further, it safely afforded significant improvement in subjective/objective BPH parameters in specific contexts/scenarios where current guidance for PAE is limited, including patients with larger prostates, prior BPH intervention, higher medical comorbidity, urinary retention, renal insufficiency, and hematuria. Altogether, PAE can be performed safely and effectively in several real-world contexts in which formal guidance for PAE is limited, and where it may offer unique advantages compared to surgical therapies.

trial registrationClinicaltrials.gov, NCT03052049. Registered 6 September 2017, https://clinicaltrials.gov/study/NCT03052049 ; Clinicaltrials.gov, NCT02026908. Registered 10 June 2019, https://cdn. CLINICALTRIALS: gov/large-docs/08/NCT02026908/Prot_SAP_000.pdf .

Indexed as

Benign prostatic hyperplasiaGuidelinesProstate artery embolizationUrology

Identifiers

PMID42909729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.