ArticleMolecular biology reports2026
Gene expression, MMGBSA, molecular and induced-fit docking of Bambusa vulgaris phytocompounds in endoplasmic reticulum stress induced by streptozotocin.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEndoplasmic reticulum stress (ERS) has been linked to insulin resistance and diabetes mellitus. Bambusa vulgaris, a tropical bamboo species widely used in traditional medicine, is used to reduce oxidative stress and as an antidiabetic agent. This study investigates the effect of B. vulgaris on ERS-related gene expression and conducts a computational analysis of B. vulgaris phytocompounds.
methodsERS was induced intraperitoneally by 60 mg/kg streptozotocin (STZ) dissolved in citrate buffer. Thirty experimental rats (n = 5) were divided into six groups: control, ERS control, metformin (100 mg/kg), and B. vulgaris aqueous extract (BV) orally administered groups (50, 100, and 200 mg/kg). Fasting blood glucose was monitored with a glucometer; RT-PCR was used for gene expression after 21 days of treatment. Molecular and induced-fit docking, free binding energy, and ADMET profiling of B. vulgaris compounds with PERK were evaluated using Schrödinger.
resultsGRP78, CHOP, ATF4, and PERK mRNA expressions were markedly (p < 0.05) upregulated relative to the control upon induction with STZ after 72 h. BV (50 and 100 mg/kg) significantly downregulated these genes' expression compared with untreated ERS rats. Luteolin and chlorogenic acid had the lowest docking scores (-10.764 kcal/mol and - 10.725 kcal/mol), with strong induced-fit scores and free binding energies (-42.2 kcal/mol and - 39.33 kcal/mol, respectively). Both comply with Lipinski's rules of drug-likeness. Isovitexin has the lowest free binding energy - 50.91 kcal/mol.
conclusionThis work suggests that BV and its compounds downregulate genes associated with ERS and promote normoglycemia.
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