ArticleTropical animal health and production2026
Mucosal disease associated with BVDV-1b and BVDV-1e in cattle in Southern Brazil.
Article in Tropical animal health and production, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Bovine viral diarrhea virus (BVDV) is an important pathogen of the global cattle industry. Fetal infection during the period of immunotolerance may result in the birth of persistently infected (PI) animals. In such animals, the emergence of or superinfection with cytopathic variants may trigger mucosal disease (MD). The objective of this study was to characterize the anatomopathological and virological aspects of two cases of MD. Animal 1, a 24-month-old presented with diarrhea, weight loss, lameness, sialorrhea, and oral and cutaneous lesions. Animal 2, a four-month-old, exhibited weight loss, intermittent diarrhea, and dehydration. Both animals were submitted to necropsy, and tissue samples from all organs were collected for histopathological evaluation. For BVDV detection, serum samples were subjected to RT-PCR and amplified products were submitted to Sanger sequencing and phylogenetic analysis. Liver and spleen fragments were used for viral isolation in MDBK cell cultures. Immunohistochemistry using the panpestiviral monoclonal antibody 15C5 was performed to detect BVDV antigen. Anatomopathological examination of Animal 1 revealed ulcerative glossitis, erosive stomatitis, erosive and ulcerative esophagitis as well as erosive and ulcerative rumenitis, erosive abomasitis, and ulcerative and crusting dermatitis affecting the nasal planum and the distal limb region. In Animal 2, ulcerative rumenitis, erosive abomasitis, and lymphoid depletion in the ileal Peyer's patches were observed. Both animals were positive for BVDV in immunohistochemistry and classified as BVDV-1e and BVDV-1b based on phylogenetic analysis. Viral isolates from both cases induced cytopathic effect between 48 and 96 h post-inoculation. This study demonstrates distinct lesion patterns in unrelated cases of MD associated with BVDV-1e and BVDV-1b in cattle, constitutes the first report of typical MD associated with these subgenotypes in Brazil.
Indexed as
Identifiers
42909690What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.