Evidence map›Paper›PMID 42909674›Full record

ArticleVeterinary research communications2026

Efficacy and economic evaluation of a novel genotype VII marker vaccine for Newcastle disease in layers.

Yin Dai, Jianguo Gao, Qiyun Zhu, Fazhi Xu, Bangzhao Cheng, Xuehuai Shen, Xuelan Liu, Yanhong Ji

Abstract read
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Article in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yin DaiAnhui Provincial Key Laboratory of Livestock and Poultry Product Safety, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Science, Hefei, 230031, China. daiyin2020@163.com.
Jianguo GaoAnhui Provincial Key Laboratory of Livestock and Poultry Product Safety, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Science, Hefei, 230031, China.
Qiyun ZhuState Key Laboratory of Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Fazhi XuCollege of Veterinary Medicine, Anhui Agricultural University, Hefei, 230036, China.
Bangzhao ChengAnimal Epidemic Prevention Station, Xuancheng, 242000, China.
Xuehuai ShenAnhui Provincial Key Laboratory of Livestock and Poultry Product Safety, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Science, Hefei, 230031, China.
Xuelan LiuCollege of Veterinary Medicine, Anhui Agricultural University, Hefei, 230036, China. liuxuelan203@163.com.
Yanhong JiState Key Laboratory of Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China. jiyanhong@caas.cn.

Funding

the China Agriculture Research System of MOF and MARA CARS-39the Open Research Project of State Key Laboratory of Animal Disease Control and Prevention SKLADCPKF202409
6 · The paper itself

Abstract

Newcastle disease (ND) poses a serious threat to poultry, with vaccination remaining the most effective control strategy. However, the widely used ND vaccine strain exhibits significant antigenic mismatch with prevalent genotype VII Newcastle disease virus (NDV), necessitating increased vaccination dosages and frequencies. This study evaluated optimization of immunization schedules for the ND marker vaccine based on genotype VII MG7 strain. Three groups were tested: Group A (4 vaccinations with inactivated ND marker vaccine), Group B (5 vaccinations with combined inactivated and live ND marker vaccines), and Group C (7 vaccinations with LaSota genotype II vaccine). Results showed that Groups A and B maintained hemagglutination inhibition antibody titers above 9 log₂ before laying and ≥ 8 log₂ during the four-month laying period, providing superior immune persistence compared to Group C. The study has confirmed that the specific ELISA test successfully distinguished between chickens that received the marked vaccine and those that did not. Furthermore, the marker vaccine strategy did not interfere with immune response to H5 and H7 subtype avian influenza vaccines. Notably, Group B achieved the highest production efficiency, with 3.01 CNY higher benefit per chicken versus Group C, while reducing vaccination stress and improving flock welfare. These findings demonstrate that the genotype VII marker vaccine is effective and provides a key tool for future ND eradication.

Indexed as

ChickensNewcastle DiseaseNewcastle disease virusPoultry DiseasesViral VaccinesAnimalsAntibodies, ViralEnzyme-Linked Immunosorbent AssayFemaleGenotypeHemagglutination Inhibition TestsVaccinationVaccines, MarkerAntibodies, ViralVaccines, MarkerViral VaccinesDisease eradicationGenotype VIIImmunization scheduleMarker vaccineNewcastle disease virus

Identifiers

PMID42909674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.